Abstract

Individuals with HIV-1 infection experience frequent bacterial pulmonary infections, even early in the course of their disease. This investigator is studying the molecular event involved in the processing and secretion of interleukin 1 beta from human monocytes and alveolar macrophages. Interleukin 1 beta has an important role in sepsis induced shock and pulmonary tissue injury. Interleukin 1b can promote and maintain inflammation via its potent effects on many tissues. For example IL-1b induces vascular endothelium to display integrins, triggers neutrophils to activation and migration, signals mesenchymal cells to proliferate and initiates a secondary cascade of cytokines such as IL-6 and IL-8. Thus IL-1b proximally controls may subsequent inflammatory events.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040871-10
Application #
2771277
Study Section
Lung Biology and Pathology Study Section (LBPA)
Project Start
1989-07-01
Project End
2001-12-31
Budget Start
1998-09-01
Budget End
2001-12-31
Support Year
10
Fiscal Year
1998
Total Cost
Indirect Cost

  Institution

Name
Ohio State University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
098987217
City
Columbus
State
OH
Country
United States
Zip Code
43210

  Publications

Malireddy, Smitha; Lawson, Courtney; Steinhour, Emily et al. (2013) Airborne agricultural particulate matter induces inflammatory cytokine secretion by respiratory epithelial cells: mechanisms of regulation by eicosanoid lipid signal mediators. Indian J Biochem Biophys 50:387-401
Kotha, Sainath R; Piper, Melissa G; Patel, Rishi B et al. (2013) Phospholipase A(2) activation by poultry particulate matter is mediated through extracellular signal-regulated kinase in lung epithelial cells: regulation of interleukin-8 release. Cell Biochem Biophys 67:415-29
Sarkar, Anasuya; Mitra, Srabani; Mehta, Sonya et al. (2009) Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS One 4:e7140
Gavrilin, Mikhail A; Mitra, Srabani; Seshadri, Sudarshan et al. (2009) Pyrin critical to macrophage IL-1beta response to Francisella challenge. J Immunol 182:7982-9
Raices, Raquel M; Kannan, Yashaswini; Bellamkonda-Athmaram, Vedavathi et al. (2009) A novel role for IkappaBzeta in the regulation of IFNgamma production. PLoS One 4:e6776
Raices, Raquel M; Kannan, Yashaswini; Sarkar, Anasuya et al. (2008) A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity. Cytokine 44:234-41
Wewers, Mark D; Marsh, Clay B (2007) Editorial. Drug Discov Today Dis Mech 4:61-62
Hall, Mark W; Gavrilin, Mikhail A; Knatz, Nina L et al. (2007) Monocyte mRNA phenotype and adverse outcomes from pediatric multiple organ dysfunction syndrome. Pediatr Res 62:597-603
Doseff, Andrea I; Baker Jr, Jon H; Bourgeois, Trevor A et al. (2003) Interleukin-4-induced apoptosis entails caspase activation and suppression of extracellular signal-regulated kinase phosphorylation. Am J Respir Cell Mol Biol 29:367-74