Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL040926-09
Application #
2219802
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1988-07-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
9
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Bloodcenter of Wisconsin, Inc.
Department
Type
DUNS #
City
Milwaukee
State
WI
Country
United States
Zip Code
53233
Liao, Danying; Mei, Heng; Hu, Yu et al. (2018) CRISPR-mediated deletion of the PECAM-1 cytoplasmic domain increases receptor lateral mobility and strengthens endothelial cell junctional integrity. Life Sci 193:186-193
Newman, Debra K; Fu, Guoping; McOlash, Laura et al. (2018) Frontline Science: PECAM-1 (CD31) expression in naïve and memory, but not acutely activated, CD8+ T cells. J Leukoc Biol 104:883-893
Paddock, Cathy; Zhou, Dongwen; Lertkiatmongkol, Panida et al. (2016) Structural basis for PECAM-1 homophilic binding. Blood 127:1052-61
Lertkiatmongkol, Panida; Liao, Danying; Mei, Heng et al. (2016) Endothelial functions of platelet/endothelial cell adhesion molecule-1 (CD31). Curr Opin Hematol 23:253-9
Newman, Debra K; Fu, Guoping; Adams, Tamara et al. (2016) The adhesion molecule PECAM-1 enhances the TGF-?-mediated inhibition of T cell function. Sci Signal 9:ra27
Privratsky, Jamie R; Newman, Peter J (2014) PECAM-1: regulator of endothelial junctional integrity. Cell Tissue Res 355:607-19
Mei, Heng; Campbell, Jay M; Paddock, Cathy M et al. (2014) Regulation of endothelial cell barrier function by antibody-driven affinity modulation of platelet endothelial cell adhesion molecule-1 (PECAM-1). J Biol Chem 289:20836-44
Tourdot, Benjamin E; Brenner, Michelle K; Keough, Kathleen C et al. (2013) Immunoreceptor tyrosine-based inhibitory motif (ITIM)-mediated inhibitory signaling is regulated by sequential phosphorylation mediated by distinct nonreceptor tyrosine kinases: a case study involving PECAM-1. Biochemistry 52:2597-608
Kuckleburg, Christopher J; Newman, Peter J (2013) Neutrophil proteinase 3 acts on protease-activated receptor-2 to enhance vascular endothelial cell barrier function. Arterioscler Thromb Vasc Biol 33:275-84
Privratsky, Jamie R; Tilkens, Sarah B; Newman, Debra K et al. (2012) PECAM-1 dampens cytokine levels during LPS-induced endotoxemia by regulating leukocyte trafficking. Life Sci 90:177-84

Showing the most recent 10 out of 48 publications