Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL043106-06A1
Application #
2220858
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1991-01-01
Project End
2000-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
6
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Duke University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
071723621
City
Durham
State
NC
Country
United States
Zip Code
27705

  Publications

Srivasatava, Kinshuk Raj; Majumder, Rinku; Kane, William H et al. (2014) Phosphatidylserine and FVa regulate FXa structure. Biochem J 459:229-39
Majumder, Rinku; Liang, Xiaoe; Quinn-Allen, Mary Ann et al. (2011) Modulation of prothrombinase assembly and activity by phosphatidylethanolamine. J Biol Chem 286:35535-42
Majumder, Rinku; Quinn-Allen, Mary Ann; Kane, William H et al. (2008) A phosphatidylserine binding site in factor Va C1 domain regulates both assembly and activity of the prothrombinase complex. Blood 112:2795-802
Jeimy, Samira B; Quinn-Allen, Mary Ann; Fuller, Nola et al. (2008) Location of the multimerin 1 binding site in coagulation factor V: an update. Thromb Res 123:352-4
Peng, W; Quinn-Allen, M A; Kane, W H (2005) Mutation of hydrophobic residues in the factor Va C1 and C2 domains blocks membrane-dependent prothrombin activation. J Thromb Haemost 3:351-4
Majumder, Rinku; Quinn-Allen, Mary Ann; Kane, William H et al. (2005) The phosphatidylserine binding site of the factor Va C2 domain accounts for membrane binding but does not contribute to the assembly or activity of a human factor Xa-factor Va complex. Biochemistry 44:711-8
Saleh, Mahasen; Peng, Weimin; Quinn-Allen, Mary Ann et al. (2004) The factor V C1 domain is involved in membrane binding: identification of functionally important amino acid residues within the C1 domain of factor V using alanine scanning mutagenesis. Thromb Haemost 91:16-27
Peng, Weimin; Quinn-Allen, Mary Ann; Kim, Suhng Wook et al. (2004) Trp2063 and Trp2064 in the factor Va C2 domain are required for high-affinity binding to phospholipid membranes but not for assembly of the prothrombinase complex. Biochemistry 43:4385-93
Hayward, Catherine P M; Fuller, Nola; Zheng, Shilun et al. (2004) Human platelets contain forms of factor V in disulfide-linkage with multimerin. Thromb Haemost 92:1349-57
Jeimy, Samira B; Woram, Rachael A; Fuller, Nola et al. (2004) Identification of the MMRN1 binding region within the C2 domain of human factor V. J Biol Chem 279:51466-71

Showing the most recent 10 out of 21 publications