Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL043617-05S1
Application #
2221101
Study Section
Special Emphasis Panel (SRC (EA))
Project Start
1989-07-01
Project End
1995-04-30
Budget Start
1993-05-01
Budget End
1995-04-30
Support Year
5
Fiscal Year
1993
Total Cost
Indirect Cost
Name
University of California San Diego
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093
Moreno-Ulloa, Aldo; Nogueira, Leonardo; Rodriguez, Alonso et al. (2015) Recovery of Indicators of Mitochondrial Biogenesis, Oxidative Stress, and Aging With (-)-Epicatechin in Senile Mice. J Gerontol A Biol Sci Med Sci 70:1370-8
Ramirez-Sanchez, Israel; De los Santos, Sergio; Gonzalez-Basurto, Silvia et al. (2014) (-)-Epicatechin improves mitochondrial-related protein levels and ameliorates oxidative stress in dystrophic ?-sarcoglycan null mouse striated muscle. FEBS J 281:5567-80
Li, Ai-Hsien; Liu, Peter P; Villarreal, Francisco J et al. (2014) Dynamic changes in myocardial matrix and relevance to disease: translational perspectives. Circ Res 114:916-27
DeCoux, Ashley; Lindsey, Merry L; Villarreal, Francisco et al. (2014) Myocardial matrix metalloproteinase-2: inside out and upside down. J Mol Cell Cardiol 77:64-72
Ortiz-Vilchis, Pilar; Yamazaki, Katrina Go; Rubio-Gayosso, Ivan et al. (2014) Co-administration of the flavanol (-)-epicatechin with doxycycline synergistically reduces infarct size in a model of ischemia reperfusion injury by inhibition of mitochondrial swelling. Eur J Pharmacol 744:76-82
Spinale, Francis G; Villarreal, Francisco (2014) Targeting matrix metalloproteinases in heart disease: lessons from endogenous inhibitors. Biochem Pharmacol 90:7-15
Gutiérrez-Salmeán, Gabriela; Ortiz-Vilchis, Pilar; Vacaseydel, Claudia M et al. (2014) Acute effects of an oral supplement of (-)-epicatechin on postprandial fat and carbohydrate metabolism in normal and overweight subjects. Food Funct 5:521-7
Gutierrez-Salmean, Gabriela; Ciaraldi, Theodore P; Nogueira, Leonardo et al. (2014) Effects of (-)-epicatechin on molecular modulators of skeletal muscle growth and differentiation. J Nutr Biochem 25:91-4
Aguilar, Hugo; Fricovsky, Eduardo; Ihm, Sang et al. (2014) Role for high-glucose-induced protein O-GlcNAcylation in stimulating cardiac fibroblast collagen synthesis. Am J Physiol Cell Physiol 306:C794-804
Moreno-Ulloa, Aldo; Romero-Perez, Diego; Villarreal, Francisco et al. (2014) Cell membrane mediated (-)-epicatechin effects on upstream endothelial cell signaling: evidence for a surface receptor. Bioorg Med Chem Lett 24:2749-52

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