Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
2R01HL044365-04A1
Application #
2221445
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1993-02-01
Project End
2001-06-30
Budget Start
1996-07-05
Budget End
1997-06-30
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Columbia University (N.Y.)
Department
Pharmacology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Barro-Soria, Rene; Rebolledo, Santiago; Liin, Sara I et al. (2014) KCNE1 divides the voltage sensor movement in KCNQ1/KCNE1 channels into two steps. Nat Commun 5:3750
Xiao, Ling; Koopmann, Tamara T; Ördög, Balázs et al. (2013) Unique cardiac Purkinje fiber transient outward current ?-subunit composition: a potential molecular link to idiopathic ventricular fibrillation. Circ Res 112:1310-22
Yu, Haibo; Lin, Zhihong; Mattmann, Margrith E et al. (2013) Dynamic subunit stoichiometry confers a progressive continuum of pharmacological sensitivity by KCNQ potassium channels. Proc Natl Acad Sci U S A 110:8732-7
Chan, Priscilla J; Osteen, Jeremiah D; Xiong, Dazhi et al. (2012) Characterization of KCNQ1 atrial fibrillation mutations reveals distinct dependence on KCNE1. J Gen Physiol 139:135-44
Li, Yong; Chen, Lei; Kass, Robert S et al. (2012) The A-kinase anchoring protein Yotiao facilitates complex formation between adenylyl cyclase type 9 and the IKs potassium channel in heart. J Biol Chem 287:29815-24
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Osteen, Jeremiah D; Barro-Soria, Rene; Robey, Seth et al. (2012) Allosteric gating mechanism underlies the flexible gating of KCNQ1 potassium channels. Proc Natl Acad Sci U S A 109:7103-8
Chen, Lei; Kass, Robert S (2011) A-kinase anchoring protein 9 and IKs channel regulation. J Cardiovasc Pharmacol 58:459-13
Wang, Kai; Terrenoire, Cecile; Sampson, Kevin J et al. (2011) Biophysical properties of slow potassium channels in human embryonic stem cell derived cardiomyocytes implicate subunit stoichiometry. J Physiol 589:6093-104
Sampson, Kevin J; Kass, Robert S (2010) Molecular mechanisms of adrenergic stimulation in the heart. Heart Rhythm 7:1151-3

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