Abstract

This grant application is aimed at improving the understanding of the contribution of impaired T cell production to the effects of HIV. First, the investigator will examineif there is impairment in lymphopoietic capacity of HIV+ bone marrows. Second, the investigator will examine the expression of gene products that regulate hematopoiesis. Third, the investigator will examine the effects of AIDS medications on T cell production.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL044851-09
Application #
6043765
Study Section
AIDS and Related Research Study Section 3 (ARRC)
Project Start
1991-02-01
Project End
2001-07-31
Budget Start
1999-08-01
Budget End
2000-07-31
Support Year
9
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199

  Publications

Kalaitzidis, Demetrios; Lee, Dongjun; Efeyan, Alejo et al. (2017) Amino acid-insensitive mTORC1 regulation enables nutritional stress resilience in hematopoietic stem cells. J Clin Invest 127:1405-1413
Palchaudhuri, Rahul; Saez, Borja; Hoggatt, Jonathan et al. (2016) Non-genotoxic conditioning for hematopoietic stem cell transplantation using a hematopoietic-cell-specific internalizing immunotoxin. Nat Biotechnol 34:738-45
Yu, Vionnie W C; Lymperi, Stefania; Oki, Toshihiko et al. (2016) Distinctive Mesenchymal-Parenchymal Cell Pairings Govern B Cell Differentiation in the Bone Marrow. Stem Cell Reports 7:220-35
Lee, Dongjun; Wang, Ying-Hua; Kalaitzidis, Demetrios et al. (2016) Endogenous transmembrane protein UT2 inhibits pSTAT3 and suppresses hematological malignancy. J Clin Invest 126:1300-10
Kfoury, Youmna; Scadden, David T (2015) Mesenchymal cell contributions to the stem cell niche. Cell Stem Cell 16:239-53
Yu, Vionnie W C; Saez, Borja; Cook, Colleen et al. (2015) Specific bone cells produce DLL4 to generate thymus-seeding progenitors from bone marrow. J Exp Med 212:759-74
Courties, Gabriel; Herisson, Fanny; Sager, Hendrik B et al. (2015) Ischemic stroke activates hematopoietic bone marrow stem cells. Circ Res 116:407-17
Wang, Weihuan; Yu, Shuiliang; Zimmerman, Grant et al. (2015) Notch Receptor-Ligand Engagement Maintains Hematopoietic Stem Cell Quiescence and Niche Retention. Stem Cells 33:2280-93
Lee, Dongjun; Sykes, Stephen M; Kalaitzidis, Demetrios et al. (2014) Transmembrane Inhibitor of RICTOR/mTORC2 in Hematopoietic Progenitors. Stem Cell Reports 3:832-40
Saez, Borja; Ferraro, Francesca; Yusuf, Rushdia Z et al. (2014) Inhibiting stromal cell heparan sulfate synthesis improves stem cell mobilization and enables engraftment without cytotoxic conditioning. Blood 124:2937-47

Showing the most recent 10 out of 72 publications