Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL045532-07
Application #
2222209
Study Section
Surgery, Anesthesiology and Trauma Study Section (SAT)
Project Start
1990-07-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
7
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Mayo Clinic, Rochester
Department
Type
DUNS #
City
Rochester
State
MN
Country
United States
Zip Code
55905
Streiff, John H; Jones, Keith A (2008) Volatile anesthetic binding to proteins is influenced by solvent and aliphatic residues. J Chem Inf Model 48:2066-73
Nakayama, Tetsuzo; Penheiter, Alan R; Penheiter, Sumedha G et al. (2006) Differential effects of volatile anesthetics on M3 muscarinic receptor coupling to the Galphaq heterotrimeric G protein. Anesthesiology 105:313-24
Hayashi, Masao; Penheiter, Sumedha G; Nakayama, Tetsuzo et al. (2006) Halothane does not inhibit the functional coupling between the beta2-adrenergic receptor and the Galphas heterotrimeric G protein. Anesthesiology 104:754-62
Streiff, John H; Allen, Thomas W; Atanasova, Elena et al. (2006) Prediction of volatile anesthetic binding sites in proteins. Biophys J 91:3405-14
Taniguchi, Miwa; Kwak, Young Lan; Jones, Keith A et al. (2006) Nitric oxide sensitivity in pulmonary artery and airway smooth muscle: a possible role for cGMP responsiveness. Am J Physiol Lung Cell Mol Physiol 290:L1018-27
Jin, Fang; Wang, Shuyan; Spencer, Joshua D et al. (2005) Effect of halothane on galphai-3 and its coupling to the M2 muscarinic receptor. Anesthesiology 103:1015-25
Nakayama, Tetsuzo; Hayashi, Masao; Warner, David O et al. (2005) Anesthetics inhibit membrane receptor coupling to the Gq/11 heterotrimeric G protein in airway smooth muscle. Anesthesiology 103:296-305
Streiff, John; Warner, David O; Klimtchuk, Elena et al. (2004) The effects of hexanol on Galpha(i) subunits of heterotrimeric G proteins. Anesth Analg 98:660-7, table of contents
Sakihara, Chie; Perkins, William J; Warner, David O et al. (2004) Anesthetics inhibit acetylcholine-promoted guanine nucleotide exchange of heterotrimeric G proteins of airway smooth muscle. Anesthesiology 101:120-6
Streiff, John H; Juranic, Nenad O; Macura, Slobodan I et al. (2004) Saturation transfer difference nuclear magnetic resonance spectroscopy as a method for screening proteins for anesthetic binding. Mol Pharmacol 66:929-35

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