Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL046417-04
Application #
2222914
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1992-02-01
Project End
1996-11-30
Budget Start
1995-02-01
Budget End
1996-11-30
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of Michigan Ann Arbor
Department
Pharmacology
Type
Schools of Medicine
DUNS #
791277940
City
Ann Arbor
State
MI
Country
United States
Zip Code
48109
Lim, William K; Kanelakis, Kimon C; Neubig, Richard R (2013) Regulation of G protein signaling by the 70kDa heat shock protein. Cell Signal 25:389-96
Myung, Chang-Seon; Lim, William K; DeFilippo, Joseph M et al. (2006) Regions in the G protein gamma subunit important for interaction with receptors and effectors. Mol Pharmacol 69:877-87
Chai, Biao-Xin; Pogozheva, Irina D; Lai, Yu-Mei et al. (2005) Receptor-antagonist interactions in the complexes of agouti and agouti-related protein with human melanocortin 1 and 4 receptors. Biochemistry 44:3418-31
Goubaeva, Farida; Ghosh, Mousumi; Malik, Sundeep et al. (2003) Stimulation of cellular signaling and G protein subunit dissociation by G protein betagamma subunit-binding peptides. J Biol Chem 278:19634-41
Soyer, Orkun S; Dimmic, Matthew W; Neubig, Richard R et al. (2003) Dimerization in aminergic G-protein-coupled receptors: application of a hidden-site class model of evolution. Biochemistry 42:14522-31
Chai, Biao-Xin; Neubig, Richard R; Millhauser, Glenn L et al. (2003) Inverse agonist activity of agouti and agouti-related protein. Peptides 24:603-9
Simons, Peter C; Shi, Mei; Foutz, Terry et al. (2003) Ligand-receptor-G-protein molecular assemblies on beads for mechanistic studies and screening by flow cytometry. Mol Pharmacol 64:1227-38
Chung, Duane A; Zuiderweg, Erik R P; Fowler, Carol B et al. (2002) NMR structure of the second intracellular loop of the alpha 2A adrenergic receptor: evidence for a novel cytoplasmic helix. Biochemistry 41:3596-604
Sarvazyan, Noune A; Lim, William K; Neubig, Richard R (2002) Fluorescence analysis of receptor-G protein interactions in cell membranes. Biochemistry 41:12858-67
Chung, Duane A; Wade, Susan M; Fowler, Carol B et al. (2002) Mutagenesis and peptide analysis of the DRY motif in the alpha2A adrenergic receptor: evidence for alternate mechanisms in G protein-coupled receptors. Biochem Biophys Res Commun 293:1233-41

Showing the most recent 10 out of 25 publications