Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047511-04
Application #
2223723
Study Section
Cardiovascular and Pulmonary Research A Study Section (CVA)
Project Start
1992-02-24
Project End
1997-01-31
Budget Start
1995-02-01
Budget End
1997-01-31
Support Year
4
Fiscal Year
1995
Total Cost
Indirect Cost
Name
Johns Hopkins University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218
Borlaug, Barry A; Kass, David A (2009) Invasive hemodynamic assessment in heart failure. Heart Fail Clin 5:217-28
Moens, An L; Leyton-Mange, Jordan S; Niu, Xiaolin et al. (2009) Adverse ventricular remodeling and exacerbated NOS uncoupling from pressure-overload in mice lacking the beta3-adrenoreceptor. J Mol Cell Cardiol 47:576-85
Moens, An L; Takimoto, Eiki; Tocchetti, Carlo G et al. (2008) Reversal of cardiac hypertrophy and fibrosis from pressure overload by tetrahydrobiopterin: efficacy of recoupling nitric oxide synthase as a therapeutic strategy. Circulation 117:2626-36
Moens, An L; Champion, Hunter C; Claeys, Marc J et al. (2008) High-dose folic acid pretreatment blunts cardiac dysfunction during ischemia coupled to maintenance of high-energy phosphates and reduces postreperfusion injury. Circulation 117:1810-9
Tocchetti, Carlo G; Wang, Wang; Froehlich, Jeffrey P et al. (2007) Nitroxyl improves cellular heart function by directly enhancing cardiac sarcoplasmic reticulum Ca2+ cycling. Circ Res 100:96-104
Li, Manxiang; Chiou, Kuan-Rau; Kass, David A (2007) Shear stress inhibition of H(2)O(2) induced p66(Shc) phosphorylation by ASK1-JNK inactivation in endothelium. Heart Vessels 22:423-7
Moens, An L; Kass, David A (2007) Therapeutic potential of tetrahydrobiopterin for treating vascular and cardiac disease. J Cardiovasc Pharmacol 50:238-46
Kass, David A; Takimoto, Eiki; Nagayama, Takahiro et al. (2007) Phosphodiesterase regulation of nitric oxide signaling. Cardiovasc Res 75:303-14
Takimoto, Eiki; Belardi, Diego; Tocchetti, Carlo G et al. (2007) Compartmentalization of cardiac beta-adrenergic inotropy modulation by phosphodiesterase type 5. Circulation 115:2159-67
Forfia, Paul R; Lee, Myung; Tunin, Richard S et al. (2007) Acute phosphodiesterase 5 inhibition mimics hemodynamic effects of B-type natriuretic peptide and potentiates B-type natriuretic peptide effects in failing but not normal canine heart. J Am Coll Cardiol 49:1079-88

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