Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL047794-03
Application #
2223883
Study Section
Cardiovascular and Renal Study Section (CVB)
Project Start
1993-12-01
Project End
1997-11-30
Budget Start
1995-12-01
Budget End
1997-11-30
Support Year
3
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Cleveland Clinic Lerner
Department
Type
DUNS #
017730458
City
Cleveland
State
OH
Country
United States
Zip Code
44195
Vasudevan, Neelakantan T; Mohan, Maradumane L; Gupta, Manveen K et al. (2013) G??-independent recruitment of G-protein coupled receptor kinase 2 drives tumor necrosis factor ?-induced cardiac ?-adrenergic receptor dysfunction. Circulation 128:377-87
Das, Biswajit; Young, David; Vasanji, Amit et al. (2010) Influence of p53 in the transition of myotrophin-induced cardiac hypertrophy to heart failure. Cardiovasc Res 87:524-34
Gupta, Anasuya; Gupta, Sudhiranjan; Young, David et al. (2010) Impairment of ultrastructure and cytoskeleton during progression of cardiac hypertrophy to heart failure. Lab Invest 90:520-30
Gupta, Sudhiranjan; Maitra, Ratan; Young, Dave et al. (2009) Silencing the myotrophin gene by RNA interference leads to the regression of cardiac hypertrophy. Am J Physiol Heart Circ Physiol 297:H627-36
Sivakumar, P; Gupta, Sudhiranjan; Sarkar, Sagartirtha et al. (2008) Upregulation of lysyl oxidase and MMPs during cardiac remodeling in human dilated cardiomyopathy. Mol Cell Biochem 307:159-67
Gupta, Sudhiranjan; Young, David; Maitra, Ratan K et al. (2008) Prevention of cardiac hypertrophy and heart failure by silencing of NF-kappaB. J Mol Biol 375:637-49
Das, Biswajit; Gupta, Sudhiranjan; Vasanji, Amit et al. (2008) Nuclear co-translocation of myotrophin and p65 stimulates myocyte growth. Regulation by myotrophin hairpin loops. J Biol Chem 283:27947-56
Gupta, Sudhiranjan; Sen, Subha (2005) Role of the NF-kappaB signaling cascade and NF-kappaB-targeted genes in failing human hearts. J Mol Med 83:993-1004
Adhikary, Gautam; Gupta, Sudhiranjan; Sil, Parames et al. (2005) Characterization and functional significance of myotrophin: a gene with multiple transcripts. Gene 353:31-40
Gupta, Sudhiranjan; Young, David; Sen, Subha (2005) Inhibition of NF-kappaB induces regression of cardiac hypertrophy, independent of blood pressure control, in spontaneously hypertensive rats. Am J Physiol Heart Circ Physiol 289:H20-9

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