In this revised application the investigators wish to pursue two main goals: expand Q2-DE to the pediatric population of patients and establish the utility of the conductance catheter method for measurement of ventricular volumes in adult patients. They also wish to study intra-operatively and at 2 and 6 weeks and 6 months postoperatively both adult and pediatric patients that had open heart surgery for a variety of valvular congenital and ischemic lesions. With the development of reliable methods to measure ventricular volume, the PI wishes to combine these data with pressure measurements to assess myocardial mechanics and edema during operation and up to six months afterwards.
| Gray, Robert G; Cabreriza, Santos E; Quinn, T Alexander et al. (2010) Feasibility of in vivo pressure measurement using a pressure-tip catheter via transventricular puncture. ASAIO J 56:194-9 |
| Spotnitz, Henry M (2010) Ventricular function in surgery for congenital heart disease. World J Surg 34:669-74 |
| Richmond, Marc E; Cabreriza, Santos E; Van Batavia, Jason P et al. (2008) Direction of preoperative ventricular shunting affects ventricular mechanics after Tetralogy of Fallot repair. Circulation 118:2338-44 |
| Berberian, George; Quinn, T Alexander; Cabreriza, Santos E et al. (2007) Left ventricular pacing site and timing optimization during biventricular pacing using a multielectrode patch in pigs. J Thorac Cardiovasc Surg 134:574-8 |
| Berberian, George; Quinn, T Alexander; Cabreriza, Santos E et al. (2006) Load dependence of cardiac output in biventricular pacing: left ventricular volume overload in pigs. J Thorac Cardiovasc Surg 131:666-70 |
| Berberian, George; Cabreriza, Santos E; Quinn, Thomas Alexander et al. (2006) Left ventricular pacing site-timing optimization during biventricular pacing using a multi-electrode patch. Ann Thorac Surg 82:2292-4 |
| Garofalo, Cara A; Cabreriza, Santos E; Quinn, T Alexander et al. (2006) Ventricular diastolic stiffness predicts perioperative morbidity and duration of pleural effusions after the Fontan operation. Circulation 114:I56-61 |
| Kenny, Jon-Emile S; Berberian, George; Rabkin, David G et al. (2006) Ethanol induction of complete heart block in swine. J Surg Res 132:142-6 |
| Quinn, T Alexander; Berberian, George; Cabreriza, Santos E et al. (2006) Effects of sequential biventricular pacing during acute right ventricular pressure overload. Am J Physiol Heart Circ Physiol 291:H2380-7 |
| Berberian, George; Kanter, Joshua P; Quinn, T Alexander et al. (2005) Optimized perioperative biventricular pacing in setting of right heart failure. Europace 7:385-7 |
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