Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048225-03
Application #
2224282
Study Section
Pharmacology A Study Section (PHRA)
Project Start
1993-09-01
Project End
1997-08-31
Budget Start
1995-09-01
Budget End
1997-08-31
Support Year
3
Fiscal Year
1995
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Verma, Rajkumar; Cronin, Chunxia G; Hudobenko, Jacob et al. (2017) Deletion of the P2X4 receptor is neuroprotective acutely, but induces a depressive phenotype during recovery from ischemic stroke. Brain Behav Immun 66:302-312
Yang, Ronghua; Beqiri, Dardan; Shen, Jian-Bing et al. (2015) P2X4 receptor-eNOS signaling pathway in cardiac myocytes as a novel protective mechanism in heart failure. Comput Struct Biotechnol J 13:1-7
Yang, Tiehong; Shen, Jian-bing; Yang, Ronghua et al. (2014) Novel protective role of endogenous cardiac myocyte P2X4 receptors in heart failure. Circ Heart Fail 7:510-8
Shen, Jian-Bing; Yang, Ronghua; Pappano, Achilles et al. (2014) Cardiac P2X purinergic receptors as a new pathway for increasing Na? entry in cardiac myocytes. Am J Physiol Heart Circ Physiol 307:H1469-77
Pereira, Flavia E; Cronin, Chunxia; Ghosh, Mallika et al. (2013) CD13 is essential for inflammatory trafficking and infarct healing following permanent coronary artery occlusion in mice. Cardiovasc Res 100:74-83
Zhou, Siyuan; Yang, Tiehong; Jacobson, Kenneth A et al. (2013) The therapeutic effect of 2-cyclohexylthio-AMP in heart failure. J Cardiovasc Pharmacol 61:553-9
Kumar, T Santhosh; Yang, Tiehong; Mishra, Shilpi et al. (2013) 5'-Phosphate and 5'-phosphonate ester derivatives of (N)-methanocarba adenosine with in vivo cardioprotective activity. J Med Chem 56:902-14
Yang, Ronghua; Liang, Bruce T (2012) Cardiac P2X(4) receptors: targets in ischemia and heart failure? Circ Res 111:397-401
Zhou, Si-Yuan; Mamdani, Mohammed; Qanud, Khaled et al. (2010) Treatment of heart failure by a methanocarba derivative of adenosine monophosphate: implication for a role of cardiac purinergic P2X receptors. J Pharmacol Exp Ther 333:920-8
Kumar, T Santhosh; Zhou, Si-Yuan; Joshi, Bhalchandra V et al. (2010) Structure-activity relationship of (N)-Methanocarba phosphonate analogues of 5'-AMP as cardioprotective agents acting through a cardiac P2X receptor. J Med Chem 53:2562-76

Showing the most recent 10 out of 41 publications