Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048276-04
Application #
2224350
Study Section
Surgery and Bioengineering Study Section (SB)
Project Start
1993-04-01
Project End
1998-03-31
Budget Start
1996-04-01
Budget End
1997-03-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Northwestern University at Chicago
Department
Engineering (All Types)
Type
Schools of Engineering
DUNS #
City
Evanston
State
IL
Country
United States
Zip Code
60201
Giammona, Lisa M; Panuganti, Swapna; Kemper, Jan M et al. (2009) Mechanistic studies on the effects of nicotinamide on megakaryocytic polyploidization and the roles of NAD+ levels and SIRT inhibition. Exp Hematol 37:1340-1352.e3
Fuhrken, Peter G; Apostolidis, Pani A; Lindsey, Stephan et al. (2008) Tumor suppressor protein p53 regulates megakaryocytic polyploidization and apoptosis. J Biol Chem 283:15589-600
Fuhrken, Peter G; Chen, Chi; Apostolidis, Pani A et al. (2008) Gene Ontology-driven transcriptional analysis of CD34+ cell-initiated megakaryocytic cultures identifies new transcriptional regulators of megakaryopoiesis. Physiol Genomics 33:159-69
Chen, Chi; Fuhrken, Peter G; Huang, Li Ting et al. (2007) A systems-biology analysis of isogenic megakaryocytic and granulocytic cultures identifies new molecular components of megakaryocytic apoptosis. BMC Genomics 8:384
Fuhrken, Peter G; Chen, Chi; Miller, William M et al. (2007) Comparative, genome-scale transcriptional analysis of CHRF-288-11 and primary human megakaryocytic cell cultures provides novel insights into lineage-specific differentiation. Exp Hematol 35:476-489
Huang, Li Ting; Paredes, Carlos J; Papoutsakis, Eleftherios T et al. (2007) Gene expression analysis illuminates the transcriptional programs underlying the functional activity of ex vivo-expanded granulocytes. Physiol Genomics 31:114-25
Giammona, Lisa M; Fuhrken, Peter G; Papoutsakis, Eleftherios T et al. (2006) Nicotinamide (vitamin B3) increases the polyploidisation and proplatelet formation of cultured primary human megakaryocytes. Br J Haematol 135:554-66
Yang, H; Miller, W M; Papoutsakis, E T (2002) Higher pH promotes megakaryocytic maturation and apoptosis. Stem Cells 20:320-8
Hevehan, Diane L; Miller, William M; Papoutsakis, Eleftherios T (2002) Differential expression and phosphorylation of distinct STAT3 proteins during granulocytic differentiation. Blood 99:1627-37
Chow, D C; Wenning, L A; Miller, W M et al. (2001) Modeling pO(2) distributions in the bone marrow hematopoietic compartment. II. Modified Kroghian models. Biophys J 81:685-96

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