Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL048522-03
Application #
2224579
Study Section
Respiratory and Applied Physiology Study Section (RAP)
Project Start
1992-08-13
Project End
1997-07-31
Budget Start
1994-08-01
Budget End
1997-07-31
Support Year
3
Fiscal Year
1994
Total Cost
Indirect Cost

  Institution

Name
Indiana University-Purdue University at Indianapolis
Department
Pediatrics
Type
Schools of Medicine
DUNS #
005436803
City
Indianapolis
State
IN
Country
United States
Zip Code
46202

  Publications

Lockett, Angelia D; Wu, Yidi; Gunst, Susan J (2018) Elastase alters contractility and promotes an inflammatory synthetic phenotype in airway smooth muscle tissues. Am J Physiol Lung Cell Mol Physiol 314:L626-L634
Zhang, Wenwu; Gunst, Susan J (2017) Non-muscle (NM) myosin heavy chain phosphorylation regulates the formation of NM myosin filaments, adhesome assembly and smooth muscle contraction. J Physiol 595:4279-4300
Zhang, Wenwu; Huang, Youliang; Gunst, Susan J (2016) p21-Activated kinase (Pak) regulates airway smooth muscle contraction by regulating paxillin complexes that mediate actin polymerization. J Physiol 594:4879-900
Wu, Yidi; Huang, Youliang; Gunst, Susan J (2016) Focal adhesion kinase (FAK) and mechanical stimulation negatively regulate the transition of airway smooth muscle tissues to a synthetic phenotype. Am J Physiol Lung Cell Mol Physiol 311:L893-L902
Wu, Yidi; Gunst, Susan J (2015) Vasodilator-stimulated phosphoprotein (VASP) regulates actin polymerization and contraction in airway smooth muscle by a vinculin-dependent mechanism. J Biol Chem 290:11403-16
Zhang, Wenwu; Huang, Youliang; Wu, Yidi et al. (2015) A novel role for RhoA GTPase in the regulation of airway smooth muscle contraction. Can J Physiol Pharmacol 93:129-36
Busk, Michael; Busk, Nancy; Puntenney, Paula et al. (2013) Use of continuous positive airway pressure reduces airway reactivity in adults with asthma. Eur Respir J 41:317-22
Xue, Z; Zhang, W; Desai, L P et al. (2013) Increased mechanical strain imposed on murine lungs during ventilation in vivo depresses airway responsiveness and activation of protein kinase Akt. J Appl Physiol (1985) 114:1506-10
Desai, Leena P; Wu, Yidi; Tepper, Robert S et al. (2011) Mechanical stimuli and IL-13 interact at integrin adhesion complexes to regulate expression of smooth muscle myosin heavy chain in airway smooth muscle tissue. Am J Physiol Lung Cell Mol Physiol 301:L275-84
Xue, Z; Yu, Y; Gao, H et al. (2011) Chronic continuous positive airway pressure (CPAP) reduces airway reactivity in vivo in an allergen-induced rabbit model of asthma. J Appl Physiol 111:353-7

Showing the most recent 10 out of 28 publications