Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL050077-04
Application #
2226190
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1993-06-01
Project End
1997-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
4
Fiscal Year
1996
Total Cost
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
004514360
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Lorenzo, Felipe R; Yang, Chunzhang; Ng Tang Fui, Mark et al. (2013) A novel EPAS1/HIF2A germline mutation in a congenital polycythemia with paraganglioma. J Mol Med (Berl) 91:507-12
Prchal, Josef T (2012) Molecular basis of polycythemic disorders due to aberrant hypoxia sensing and its relevance to acute leukemia. Best Pract Res Clin Haematol 25:493-7
Lorenzo 5th, Felipe R; Phillips, John D; Nussenzveig, Roberto et al. (2011) Molecular basis of two novel mutations found in type I methemoglobinemia. Blood Cells Mol Dis 46:277-81
Gordeuk, Victor R; Miasnikova, Galina Y; Sergueeva, Adelina I et al. (2011) Chuvash polycythemia VHLR200W mutation is associated with down-regulation of hepcidin expression. Blood 118:5278-82
Miasnikova, Galina Y; Sergueeva, Adelina I; Nouraie, Mehdi et al. (2011) The heterozygote advantage of the Chuvash polycythemia VHLR200W mutation may be protection against anemia. Haematologica 96:1371-4
Yoon, Donghoon; Okhotin, David V; Kim, Bumjun et al. (2010) Increased size of solid organs in patients with Chuvash polycythemia and in mice with altered expression of HIF-1alpha and HIF-2alpha. J Mol Med (Berl) 88:523-30
Simonson, Tatum S; Yang, Yingzhong; Huff, Chad D et al. (2010) Genetic evidence for high-altitude adaptation in Tibet. Science 329:72-5
Huang, Xiaosong; Pierce, L Jeanne; Chen, George L et al. (2010) Erythropoietin receptor signaling regulates both erythropoiesis and megakaryopoiesis in vivo. Blood Cells Mol Dis 44:1-6
Bruchova, Hana; Yoon, Donghoon; Agarwal, Archana M et al. (2009) Erythropoiesis in polycythemia vera is hyper-proliferative and has accelerated maturation. Blood Cells Mol Dis 43:81-7
Lorenzo, V Felipe; Yang, Yingzhong; Simonson, Tatum S et al. (2009) Genetic adaptation to extreme hypoxia: study of high-altitude pulmonary edema in a three-generation Han Chinese family. Blood Cells Mol Dis 43:221-5

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