Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL052243-02
Application #
2229521
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1994-12-01
Project End
1998-11-30
Budget Start
1995-12-01
Budget End
1996-11-30
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Dartmouth College
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
041027822
City
Hanover
State
NH
Country
United States
Zip Code
03755

  Publications

Boosalis, Michael S; Castaneda, Serguei A; Trudel, Marie et al. (2011) Novel therapeutic candidates, identified by molecular modeling, induce ?-globin gene expression in vivo. Blood Cells Mol Dis 47:107-16
Mabaera, Rodwell; West, Rachel J; Conine, Sarah J et al. (2008) A cell stress signaling model of fetal hemoglobin induction: what doesn't kill red blood cells may make them stronger. Exp Hematol 36:1057-72
Layon, Michael E; Ackley, Catherine J; West, Rachel J et al. (2007) Expression of GATA-1 in a non-hematopoietic cell line induces beta-globin locus control region chromatin structure remodeling and an erythroid pattern of gene expression. J Mol Biol 366:737-44
Mabaera, Rodwell; Richardson, Christine A; Johnson, Kristin et al. (2007) Developmental- and differentiation-specific patterns of human gamma- and beta-globin promoter DNA methylation. Blood 110:1343-52
Ermentrout, R Mitchell; Layon, Michael E; Ackley, Catherine J et al. (2006) The effects of lead and cadmium on GATA-1 regulated erythroid gene expression. Blood Cells Mol Dis 37:164-72
Mankidy, Rishikesh; Faller, Douglas V; Mabaera, Rodwell et al. (2006) Short-chain fatty acids induce gamma-globin gene expression by displacement of a HDAC3-NCoR repressor complex. Blood 108:3179-86
Nemeth, Michael J; Lowrey, Christopher H (2004) An Erythroid-Specific Chromatin Opening Element Increases beta-Globin Gene Expression from Integrated Retroviral Gene Transfer Vectors. Gene Ther Mol Biol 8:475-486
Kitareewan, Sutisak; Pitha-Rowe, Ian; Sekula, David et al. (2002) UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia. Proc Natl Acad Sci U S A 99:3806-11
Nemeth, M J; Bodine, D M; Garrett, L J et al. (2001) An erythroid-specific chromatin opening element reorganizes beta-globin promoter chromatin structure and augments gene expression. Blood Cells Mol Dis 27:767-80
Goodwin, A J; McInerney, J M; Glander, M A et al. (2001) In vivo formation of a human beta-globin locus control region core element requires binding sites for multiple factors including GATA-1, NF-E2, erythroid Kruppel-like factor, and Sp1. J Biol Chem 276:26883-92

Showing the most recent 10 out of 15 publications