This competitive renewal application requests support to continue a study of hypertension in populations of West African origin. During the first cycle 4,000 family members were recruited from Nigeria, Jamaica, and metropolitan Chicago, IL. Epidemiologic and genetic relationships have been demonstrated for angiotensin I-converting enzyme (ACE) and angiotensinogen (AGT). These genetically related populations live in highly contrasting social settings and a major focus of this project is how environment influences the expression of hypertension-related traits. Substantial differences in familial patterns have been identified in comparisons among the three population samples, suggesting gene-environment interactions. In this renewal phase the total sample will be increased to 6,000 family members. To further elucidate the environmental pathways we will conduct a sub-study cross-classifying participants on the major risk determinants (ie, obesity and sodium intake) and examine gene-environment interactions directly. A genome scan will be used in linkage analysis to identify new chromosomal regions of interest. Two new candidate loci (adducin and beta-2 adrenergic receptor) will be examined and association studies will be conducted using single nucleotide polymorphisms. The full range of analytic tools, including segregation, linkage and cladistic analysis, will be used.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL053353-07
Application #
6659802
Study Section
Epidemiology and Disease Control Subcommittee 2 (EDC)
Program Officer
Sorlie, Paul
Project Start
1995-09-30
Project End
2005-03-31
Budget Start
2003-08-01
Budget End
2005-03-31
Support Year
7
Fiscal Year
2003
Total Cost
$528,863
Indirect Cost
Name
Loyola University Chicago
Department
Public Health & Prev Medicine
Type
Schools of Medicine
DUNS #
791277940
City
Maywood
State
IL
Country
United States
Zip Code
60153
Justice, Anne E (see original citation for additional authors) (2017) Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits. Nat Commun 8:14977
Nandakumar, Priyanka; Lee, Dongwon; Richard, Melissa A et al. (2017) Rare coding variants associated with blood pressure variation in 15?914 individuals of African ancestry. J Hypertens 35:1381-1389
Wang, Heming; Choi, Yoonha; Tayo, Bamidele et al. (2017) Genome-wide survey in African Americans demonstrates potential epistasis of fitness in the human genome. Genet Epidemiol 41:122-135
Tayo, Bamidele O; Tong, Liping; Cooper, Richard S (2016) Association of polymorphisms in the aldosterone-regulated sodium reabsorption pathway with blood pressure among Hispanics. BMC Proc 10:343-348
Ehret, Georg B (see original citation for additional authors) (2016) The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals. Nat Genet 48:1171-1184
Eckberg, Karl; Kramer, Holly; Wolf, Myles et al. (2015) Impact of westernization on fibroblast growth factor 23 levels among individuals of African ancestry. Nephrol Dial Transplant 30:630-5
Zhu, Xiaofeng; Feng, Tao; Tayo, Bamidele O et al. (2015) Meta-analysis of correlated traits via summary statistics from GWASs with an application in hypertension. Am J Hum Genet 96:21-36
Akingbola, Titilola S; Tayo, Bamidele O; Salako, Babatunde et al. (2014) Comparison of patients from Nigeria and the USA highlights modifiable risk factors for sickle cell anemia complications. Hemoglobin 38:236-43
Adeoye, Abiodun M; Adebiyi, Adewole; Tayo, Bamidele O et al. (2014) Hypertension Subtypes among Hypertensive Patients in Ibadan. Int J Hypertens 2014:295916
Wang, Ya-Juan; Tayo, Bamidele O; Bandyopadhyay, Anupam et al. (2014) The association of the vanin-1 N131S variant with blood pressure is mediated by endoplasmic reticulum-associated degradation and loss of function. PLoS Genet 10:e1004641

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