Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054083-09
Application #
6765894
Study Section
Hematology Subcommittee 2 (HEM)
Program Officer
Thomas, John
Project Start
1996-04-01
Project End
2006-06-30
Budget Start
2004-07-01
Budget End
2006-06-30
Support Year
9
Fiscal Year
2004
Total Cost
$361,250
Indirect Cost
Name
University of Florida
Department
Genetics
Type
Schools of Medicine
DUNS #
969663814
City
Gainesville
State
FL
Country
United States
Zip Code
32611
Cheng, Xiaodong; Byrne, Michael; Brown, Kevin D et al. (2015) PKR inhibits the DNA damage response, and is associated with poor survival in AML and accelerated leukemia in NHD13 mice. Blood 126:1585-94
Byrne, Michael; Bennett, Richard L; Cheng, Xiaodong et al. (2014) Progressive genomic instability in the Nup98-HoxD13 model of MDS correlates with loss of the PIG-A gene product. Neoplasia 16:627-33
Cheng, X; Bennett, R L; Liu, X et al. (2013) PKR negatively regulates leukemia progression in association with PP2A activation, Bcl-2 inhibition and increased apoptosis. Blood Cancer J 3:e144
Liu, Xiangfei; Bennett, Richard L; Cheng, Xiaodong et al. (2013) PKR regulates proliferation, differentiation, and survival of murine hematopoietic stem/progenitor cells. Blood 121:3364-74
Bennett, Richard L; Pan, Yu; Christian, Jaime et al. (2012) The RAX/PACT-PKR stress response pathway promotes p53 sumoylation and activation, leading to G? arrest. Cell Cycle 11:407-17
Bennett, Richard L; Carruthers, Aubrey L; Hui, Teng et al. (2012) Increased expression of the dsRNA-activated protein kinase PKR in breast cancer promotes sensitivity to doxorubicin. PLoS One 7:e46040
Bennett, Richard L; Blalock, William L; Choi, Eun-Jung et al. (2008) RAX is required for fly neuronal development and mouse embryogenesis. Mech Dev 125:777-85
Bennett, Richard L; Blalock, William L; Abtahi, Dean M et al. (2006) RAX, the PKR activator, sensitizes cells to inflammatory cytokines, serum withdrawal, chemotherapy, and viral infection. Blood 108:821-9
Bennett, Richard L; Blalock, William L; May, W Stratford (2004) Serine 18 phosphorylation of RAX, the PKR activator, is required for PKR activation and consequent translation inhibition. J Biol Chem 279:42687-93
Varma, Tushar; Liu, Si Qi; West, Matthew et al. (2003) Protein kinase C-dependent phosphorylation and mitochondrial translocation of aldose reductase. FEBS Lett 534:175-9

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