Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054887-02
Application #
2233383
Study Section
Physiology Study Section (PHY)
Project Start
1995-07-01
Project End
2000-05-31
Budget Start
1996-06-01
Budget End
1997-05-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost
Name
State University of New York at Buffalo
Department
Physiology
Type
Schools of Medicine
DUNS #
038633251
City
Buffalo
State
NY
Country
United States
Zip Code
14260
Sachs, Frederick (2018) Mechanical Transduction and the Dark Energy of Biology. Biophys J 114:3-9
Maneshi, Mohammad Mehdi; Maki, Bruce; Gnanasambandam, Radhakrishnan et al. (2017) Mechanical stress activates NMDA receptors in the absence of agonists. Sci Rep 7:39610
Verma, Deepika; Bajpai, Vivek K; Ye, Nannan et al. (2017) Flow induced adherens junction remodeling driven by cytoskeletal forces. Exp Cell Res 359:327-336
Gnanasambandam, Radhakrishnan; Ghatak, Chiranjib; Yasmann, Anthony et al. (2017) GsMTx4: Mechanism of Inhibiting Mechanosensitive Ion Channels. Biophys J 112:31-45
Gnanasambandam, R; Gottlieb, P A; Sachs, F (2017) The Kinetics and the Permeation Properties of Piezo Channels. Curr Top Membr 79:275-307
Zheng, Wenjun; Sachs, Frederick (2017) Investigating the structural dynamics of the PIEZO1 channel activation and inactivation by coarse-grained modeling. Proteins 85:2198-2208
Suchyna, Thomas M (2017) Piezo channels and GsMTx4: Two milestones in our understanding of excitatory mechanosensitive channels and their role in pathology. Prog Biophys Mol Biol 130:244-253
Wang, Jinli; Ma, Yina; Sachs, Frederick et al. (2016) GsMTx4-D is a cardioprotectant against myocardial infarction during ischemia and reperfusion. J Mol Cell Cardiol 98:83-94
Peng, Anthony W; Gnanasambandam, Radhakrishnan; Sachs, Frederick et al. (2016) Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer. J Neurosci 36:2945-56
Bae, Chilman; Suchyna, Thomas M; Ziegler, Lynn et al. (2016) Human PIEZO1 Ion Channel Functions as a Split Protein. PLoS One 11:e0151289

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