Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL054977-02
Application #
2233508
Study Section
Experimental Immunology Study Section (EI)
Project Start
1995-08-01
Project End
1998-07-31
Budget Start
1996-08-01
Budget End
1997-07-31
Support Year
2
Fiscal Year
1996
Total Cost
Indirect Cost

  Institution

Name
Pennsylvania State University
Department
Microbiology/Immun/Virology
Type
Schools of Medicine
DUNS #
129348186
City
Hershey
State
PA
Country
United States
Zip Code
17033

  Publications

Gilchuk, Pavlo; Hill, Timothy M; Guy, Clifford et al. (2016) A Distinct Lung-Interstitium-Resident Memory CD8(+) T Cell Subset Confers Enhanced Protection to Lower Respiratory Tract Infection. Cell Rep 16:1800-9
Hastings, Andrew K; Gilchuk, Pavlo; Joyce, Sebastian et al. (2016) Novel HLA-A2-restricted human metapneumovirus epitopes reduce viral titers in mice and are recognized by human T cells. Vaccine 34:2663-70
Spencer, Charles T; Bezbradica, Jelena S; Ramos, Mireya G et al. (2015) Viral infection causes a shift in the self peptide repertoire presented by human MHC class I molecules. Proteomics Clin Appl 9:1035-52
Erickson, John J; Lu, Pengcheng; Wen, Sherry et al. (2015) Acute Viral Respiratory Infection Rapidly Induces a CD8+ T Cell Exhaustion-like Phenotype. J Immunol 195:4319-30
Gilchuk, Pavlo; Hill, Timothy M; Wilson, John T et al. (2015) Discovering protective CD8 T cell epitopes--no single immunologic property predicts it! Curr Opin Immunol 34:43-51
Hastings, Andrew K; Erickson, John J; Schuster, Jennifer E et al. (2015) Role of type I interferon signaling in human metapneumovirus pathogenesis and control of viral replication. J Virol 89:4405-20
Gilchuk, Pavlo; Spencer, Charles T; Conant, Stephanie B et al. (2013) Discovering naturally processed antigenic determinants that confer protective T cell immunity. J Clin Invest 123:1976-87
Spencer, Charles T; Dragovic, Srdjan M; Conant, Stephanie B et al. (2013) Sculpting MHC class II-restricted self and non-self peptidome by the class I Ag-processing machinery and its impact on Th-cell responses. Eur J Immunol 43:1162-72
Erickson, John J; Gilchuk, Pavlo; Hastings, Andrew K et al. (2012) Viral acute lower respiratory infections impair CD8+ T cells through PD-1. J Clin Invest 122:2967-82
Boelte, Kimberly C; Gordy, Laura E; Joyce, Sebastian et al. (2011) Rgs2 mediates pro-angiogenic function of myeloid derived suppressor cells in the tumor microenvironment via upregulation of MCP-1. PLoS One 6:e18534

Showing the most recent 10 out of 30 publications