Abstract

The proposed studies are specifically designed to test the following hypotheses: (1) stretch-initiated transduction in fetal type II cells triggers PTHrP production; (2) PTHrP stimulates fetal lung fibroblast maturation by receptor-dependent mechanisms; (3) PTHrP stimulates production of mesenchymal cytokines and growth factors which promote type II cell maturation. Elaboration of lipoprotein lipase, glucocorticoid receptor, and PTHrP-regulated fibroblast growth factors and cytokines by PTHrP-deficient lung tissue and fibroblasts will be studied at the mRNA and protein levels to determine which functions are affected in this model.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL055268-04
Application #
6043863
Study Section
Human Embryology and Development Subcommittee 1 (HED)
Project Start
1997-08-01
Project End
2001-07-31
Budget Start
1999-08-01
Budget End
2001-07-31
Support Year
4
Fiscal Year
1999
Total Cost
Indirect Cost

  Institution

Name
La Biomed Research Institute/ Harbor UCLA Medical Center
Department
Type
DUNS #
City
Torrance
State
CA
Country
United States
Zip Code
90502

  Publications

Torday, John S; Miller Jr, William B (2017) The resolution of ambiguity as the basis for life: A cellular bridge between Western reductionism and Eastern holism. Prog Biophys Mol Biol 131:288-297
Torday, John S; Miller, William B (2016) Phenotype as Agent for Epigenetic Inheritance. Biology (Basel) 5:
Torday, John S; Miller Jr, William B (2016) Biologic relativity: Who is the observer and what is observed? Prog Biophys Mol Biol 121:29-34
Torday, John S; Miller Jr, William B (2016) Life is determined by its environment. Int J Astrobiol 15:345-350
Torday, John S (2016) Life Is Simple-Biologic Complexity Is an Epiphenomenon. Biology (Basel) 5:
Torday, John S; Miller, William B (2016) The Unicellular State as a Point Source in a Quantum Biological System. Biology (Basel) 5:
Torday, John S (2016) The Emergence of Physiology and Form: Natural Selection Revisited. Biology (Basel) 5:
Torday, John S (2016) The Cell as the First Niche Construction. Biology (Basel) 5:
Torday, John S; Rehan, Virender K (2016) On the evolution of the pulmonary alveolar lipofibroblast. Exp Cell Res 340:215-9
Torday, John S (2016) Heterochrony as Diachronically Modified Cell-Cell Interactions. Biology (Basel) 5:

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