Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
1R01HL056181-01
Application #
2234780
Study Section
Hematology Subcommittee 2 (HEM)
Project Start
1996-07-01
Project End
2001-06-30
Budget Start
1996-07-01
Budget End
1997-06-30
Support Year
1
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Vanderbilt University Medical Center
Department
Pathology
Type
Schools of Medicine
DUNS #
004413456
City
Nashville
State
TN
Country
United States
Zip Code
37212
Davis 4th, Richard W; Eggleston, Heather; Johnson, Frances et al. (2015) In Vivo Tracking of Streptococcal Infections of Subcutaneous Origin in a Murine Model. Mol Imaging Biol 17:793-801
Verhamme, I M; Panizzi, P R; Bock, P E (2015) Pathogen activators of plasminogen. J Thromb Haemost 13 Suppl 1:S106-14
Verhamme, Ingrid M; Bock, Paul E (2014) Rapid binding of plasminogen to streptokinase in a catalytic complex reveals a three-step mechanism. J Biol Chem 289:28006-18
Nolan, Miranda; Bouldin, Samantha D; Bock, Paul E (2013) Full time course kinetics of the streptokinase-plasminogen activation pathway. J Biol Chem 288:29482-93
Laha, Malabika; Panizzi, Peter; Nahrendorf, Matthias et al. (2011) Engineering streptokinase for generation of active site-labeled plasminogen analogs. Anal Biochem 415:105-15
Wiles, Karen G; Panizzi, Peter; Kroh, Heather K et al. (2010) Skizzle is a novel plasminogen- and plasmin-binding protein from Streptococcus agalactiae that targets proteins of human fibrinolysis to promote plasmin generation. J Biol Chem 285:21153-64
Tharp, Anthony C; Laha, Malabika; Panizzi, Peter et al. (2009) Plasminogen substrate recognition by the streptokinase-plasminogen catalytic complex is facilitated by Arg253, Lys256, and Lys257 in the streptokinase beta-domain and kringle 5 of the substrate. J Biol Chem 284:19511-21
Verhamme, Ingrid M; Bock, Paul E (2008) Rapid-reaction kinetic characterization of the pathway of streptokinase-plasmin catalytic complex formation. J Biol Chem 283:26137-47
Panizzi, Peter; Boxrud, Paul D; Verhamme, Ingrid M et al. (2006) Binding of the COOH-terminal lysine residue of streptokinase to plasmin(ogen) kringles enhances formation of the streptokinase.plasmin(ogen) catalytic complexes. J Biol Chem 281:26774-8
Bean, Ronald R; Verhamme, Ingrid M; Bock, Paul E (2005) Role of the streptokinase alpha-domain in the interactions of streptokinase with plasminogen and plasmin. J Biol Chem 280:7504-10

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