In this proposal, the applicant will investigate the role of the C-EBP-alpha transcription factor in the development of myeloid cells. It is proposed that this factor plays a key role in the differentiation of such cells from multipotential progenitors. Another transcription factor, PU.1, is an important regulator of myeloid development and, together with C-EBP-alpha, is believed to regulate the promoters for a number of important genes essential for myeloid differentiation.
The specific aims are to delineate the role of C-EBP- alpha in myeloid development as well as to define its interaction with PU.1. Thus, the applicant will determine the mechanisms by which C-EBP factors regulate the expression of genes important for myeloid development with particular emphasis on the interaction between C-EBP- alpha and PU.1. He will also determine the effects on targeted disruption of the murine C-EBP-alpha gene on myeloid development in mice and in embryonic stem cells. These studies will be important towards furthering our understanding of hematopoietic lineage development.
| Welner, Robert S; Bararia, Deepak; Amabile, Giovanni et al. (2013) C/EBP? is required for development of dendritic cell progenitors. Blood 121:4073-81 |
| Ye, Min; Zhang, Hong; Amabile, Giovanni et al. (2013) C/EBPa controls acquisition and maintenance of adult haematopoietic stem cell quiescence. Nat Cell Biol 15:385-94 |
| Di Ruscio, Annalisa; Ebralidze, Alexander K; Benoukraf, Touati et al. (2013) DNMT1-interacting RNAs block gene-specific DNA methylation. Nature 503:371-6 |
| Yong, Kol Jia; Gao, Chong; Lim, Joline S J et al. (2013) Oncofetal gene SALL4 in aggressive hepatocellular carcinoma. N Engl J Med 368:2266-76 |
| Zhang, Hong; Alberich-Jorda, Meritxell; Amabile, Giovanni et al. (2013) Sox4 is a key oncogenic target in C/EBP? mutant acute myeloid leukemia. Cancer Cell 24:575-88 |
| Chen, Leilei; Li, Yan; Lin, Chi Ho et al. (2013) Recoding RNA editing of AZIN1 predisposes to hepatocellular carcinoma. Nat Med 19:209-16 |
| Alberich-Jordà , Meritxell; Wouters, Bas; Balastik, Martin et al. (2012) C/EBP? deregulation results in differentiation arrest in acute myeloid leukemia. J Clin Invest 122:4490-504 |
| Jiang, Shuxian; Alberich-Jorda, Meritxell; Zagozdzon, Radoslaw et al. (2011) Cannabinoid receptor 2 and its agonists mediate hematopoiesis and hematopoietic stem and progenitor cell mobilization. Blood 117:827-38 |
| Blanchet, Marie-Renee; Bennett, Jami L; Gold, Matthew J et al. (2011) CD34 is required for dendritic cell trafficking and pathology in murine hypersensitivity pneumonitis. Am J Respir Crit Care Med 184:687-98 |
| Grandinetti, K B; Stevens, T A; Ha, S et al. (2011) Overexpression of TRIB2 in human lung cancers contributes to tumorigenesis through downregulation of C/EBP?. Oncogene 30:3328-35 |
Showing the most recent 10 out of 30 publications
