Abstract

The proposal seeks to link the hypothesis that children with inherently increased upper airway collapsibility are at risk for developing obstructive sleep apnea during both childhood and adulthood. The investigators propose to examine the changes in airway collapsibility that occur during childhood, and then compare normal children with children who are identified a having OSAS.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL058585-04
Application #
6389698
Study Section
Special Emphasis Panel (ZRG2-PHY (01))
Program Officer
Twery, Michael
Project Start
1998-07-06
Project End
2002-06-30
Budget Start
2001-07-01
Budget End
2002-06-30
Support Year
4
Fiscal Year
2001
Total Cost
$170,379
Indirect Cost

  Institution

Name
Johns Hopkins University
Department
Pediatrics
Type
Schools of Medicine
DUNS #
045911138
City
Baltimore
State
MD
Country
United States
Zip Code
21218

  Publications

Busch, David R; Lynch, Jennifer M; Winters, Madeline E et al. (2016) Cerebral Blood Flow Response to Hypercapnia in Children with Obstructive Sleep Apnea Syndrome. Sleep 39:209-16
Konstantinopoulou, Sofia; Tapia, Ignacio E; Kim, Ji Young et al. (2016) Relationship between obstructive sleep apnea cardiac complications and sleepiness in children with Down syndrome. Sleep Med 17:18-24
Xanthopoulos, Melissa S; Gallagher, Paul R; Berkowitz, Robert I et al. (2015) Neurobehavioral functioning in adolescents with and without obesity and obstructive sleep apnea. Sleep 38:401-10
Tapia, Ignacio E; McDonough, Joseph M; Huang, Jingtao et al. (2015) Respiratory cortical processing to inspiratory resistances during wakefulness in children with the obstructive sleep apnea syndrome. J Appl Physiol (1985) 118:400-7
Cielo, Christopher M; Marcus, Carole L (2015) Obstructive sleep apnoea in children with craniofacial syndromes. Paediatr Respir Rev 16:189-96
Schwab, Richard J; Kim, Christopher; Bagchi, Sheila et al. (2015) Understanding the anatomic basis for obstructive sleep apnea syndrome in adolescents. Am J Respir Crit Care Med 191:1295-309
Koren, D; Chirinos, J A; Katz, L E L et al. (2015) Interrelationships between obesity, obstructive sleep apnea syndrome and cardiovascular risk in obese adolescents. Int J Obes (Lond) 39:1086-93
King, Michelle S; Xanthopoulos, Melissa S; Marcus, Carole L (2014) Improving Positive Airway Pressure Adherence in Children. Sleep Med Clin 9:219-234
Thongyam, Anchana; Marcus, Carole L; Lockman, Justin L et al. (2014) Predictors of perioperative complications in higher risk children after adenotonsillectomy for obstructive sleep apnea: a prospective study. Otolaryngol Head Neck Surg 151:1046-54
Marcus, Carole L (2014) Arousal threshold in obstructive sleep apnea. Am J Respir Crit Care Med 189:372-3

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