Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
3R01HL062198-04S1
Application #
6866064
Study Section
Bio-Organic and Natural Products Chemistry Study Section (BNP)
Program Officer
Werner, Ellen
Project Start
2000-09-10
Project End
2007-11-30
Budget Start
2003-12-04
Budget End
2004-11-30
Support Year
4
Fiscal Year
2004
Total Cost
$30,279
Indirect Cost
Name
Wake Forest University Health Sciences
Department
Chemistry
Type
Schools of Arts and Sciences
DUNS #
041418799
City
Winston-Salem
State
NC
Country
United States
Zip Code
27106
Miao, Zhengrui; King, S Bruce (2016) Recent advances in the chemical biology of nitroxyl (HNO) detection and generation. Nitric Oxide 57:1-14
Mohamed, Heba A H; Abdel-Aziz, Mohamed; Abuo-Rahma, Gamal El-Din A A et al. (2015) New acyloxy nitroso compounds with improved water solubility and nitroxyl (HNO) release kinetics and inhibitors of platelet aggregation. Bioorg Med Chem 23:6069-77
Clodfelter, William H; Basu, Swati; Bolden, Crystal et al. (2015) The relationship between plasma and salivary NOx. Nitric Oxide 47:85-90
Miao, Zhengrui; Reisz, Julie A; Mitroka, Susan M et al. (2015) A selective phosphine-based fluorescent probe for nitroxyl in living cells. Bioorg Med Chem Lett 25:16-9
Hadimani, Mallinath B; Mukherjee, Rajeswari; Banerjee, Ranjan et al. (2015) Ring expansions of acyloxy nitroso compounds. Tetrahedron Lett 56:5870-5873
Zhang, Di; Chen, Wei; Miao, Zhengrui et al. (2014) A reductive ligation based fluorescent probe for S-nitrosothiols. Chem Commun (Camb) 50:4806-9
Bellavia, Landon; DuMond, Jenna F; Perlegas, Andreas et al. (2013) Nitroxyl accelerates the oxidation of oxyhemoglobin by nitrite. Nitric Oxide 31:38-47
Donzelli, Sonia; Fischer, Gerry; King, Bruce S et al. (2013) Pharmacological characterization of 1-nitrosocyclohexyl acetate, a long-acting nitroxyl donor that shows vasorelaxant and antiaggregatory effects. J Pharmacol Exp Ther 344:339-47
Bruce King, S (2013) Potential biological chemistry of hydrogen sulfide (H2S) with the nitrogen oxides. Free Radic Biol Med 55:1-7
Mitroka, Susan; Shoman, Mai E; DuMond, Jenna F et al. (2013) Direct and nitroxyl (HNO)-mediated reactions of acyloxy nitroso compounds with the thiol-containing proteins glyceraldehyde 3-phosphate dehydrogenase and alkyl hydroperoxide reductase subunit C. J Med Chem 56:6583-92

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