Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL062454-02
Application #
6184791
Study Section
Pathology A Study Section (PTHA)
Project Start
1999-04-01
Project End
2003-03-31
Budget Start
2000-04-01
Budget End
2001-03-31
Support Year
2
Fiscal Year
2000
Total Cost
$292,886
Indirect Cost
Name
Columbia University (N.Y.)
Department
Obstetrics & Gynecology
Type
Schools of Medicine
DUNS #
167204994
City
New York
State
NY
Country
United States
Zip Code
10032
Kangsamaksin, Thaned; Murtomaki, Aino; Kofler, Natalie M et al. (2015) NOTCH decoys that selectively block DLL/NOTCH or JAG/NOTCH disrupt angiogenesis by unique mechanisms to inhibit tumor growth. Cancer Discov 5:182-97
Kangsamaksin, Thaned; Tattersall, Ian W; Kitajewski, Jan (2014) Notch functions in developmental and tumour angiogenesis by diverse mechanisms. Biochem Soc Trans 42:1563-8
England, Ryan W; Hardy, Krista L; Kitajewski, Alex M et al. (2014) Propranolol promotes accelerated and dysregulated adipogenesis in hemangioma stem cells. Ann Plast Surg 73 Suppl 1:S119-24
Pajvani, Utpal B; Qiang, Li; Kangsamaksin, Thaned et al. (2013) Inhibition of Notch uncouples Akt activation from hepatic lipid accumulation by decreasing mTorc1 stability. Nat Med 19:1054-60
Wong, Alvin; Hardy, Krista L; Kitajewski, Alex M et al. (2012) Propranolol accelerates adipogenesis in hemangioma stem cells and causes apoptosis of hemangioma endothelial cells. Plast Reconstr Surg 130:1012-21
Tung, Jennifer J; Tattersall, Ian W; Kitajewski, Jan (2012) Tips, stalks, tubes: notch-mediated cell fate determination and mechanisms of tubulogenesis during angiogenesis. Cold Spring Harb Perspect Med 2:a006601
Kofler, Natalie M; Shawber, Carrie J; Kangsamaksin, Thaned et al. (2011) Notch signaling in developmental and tumor angiogenesis. Genes Cancer 2:1106-16
Kitajewski, Jan (2011) Fine-tuning endothelial Notch: SIRT-ainly an unexpected mechanism. Dev Cell 20:577-8
Outtz, Hasina H; Tattersall, Ian W; Kofler, Natalie M et al. (2011) Notch1 controls macrophage recruitment and Notch signaling is activated at sites of endothelial cell anastomosis during retinal angiogenesis in mice. Blood 118:3436-9
Hunkapiller, Nathan M; Gasperowicz, Malgorzata; Kapidzic, Mirhan et al. (2011) A role for Notch signaling in trophoblast endovascular invasion and in the pathogenesis of pre-eclampsia. Development 138:2987-98

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