: Cardiovascular disease remains the number one cause of death in the United States today. In addition to a plethora of genetic and environmental factors, the diet and lifestyle of Western populations continues to have a profound negative impact on the prevalence of atherosclerotic disease. Significant advances have been made in the management and treatment of the clinical sequalae of this disease process. However, many of these treatments are geared towards the management of catastrophic clinical events. Our understanding of the basic biology of the atherosclerotic lesion is still lacking in terms of a complete and fundamental understanding of the basic biology of the atherosclerotic lesion. The proposed Bioengineering Research Partnership (BRP) will be dedicated to establishing a consortium of investigators from Emory University School of Medicine and The Georgia Institute of Technology devoted to obtaining a greater understanding of the biology and engineering of this fundamental problem of great clinical importance. This BRP will expand upon established collaborations to incorporate expertise in basic vascular biology, imaging technologies, fluid mechanics, arterial wall mechanics, cardiac surgery, and interventional cardiology. We shall make use of explanted human hearts obtained from cardiac transplant recipients to provide a unique, model system to study living, human arteries with established atherosclerosis. The in vivo studies will be augmented by a series of cell culture studies designed to explicitly examine the effects of defined mechanical forces on inflammatory responses and apoptosis in a controlled setting. Finally, the impact of placement of clinically used coronary artery stents on the mechanical and subsequent biological responses of the arterial wall will be examined.

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL070531-03
Application #
6753485
Study Section
Special Emphasis Panel (ZRG1-SSS-M (02))
Program Officer
Wassef, Momtaz K
Project Start
2002-06-01
Project End
2007-05-31
Budget Start
2004-06-01
Budget End
2005-05-31
Support Year
3
Fiscal Year
2004
Total Cost
$1,330,481
Indirect Cost
Name
Emory University
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
066469933
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Wang, Ruoya; Raykin, Julia; Brewster, Luke P et al. (2017) A Novel Approach to Assess the In Situ Versus Ex Vivo Mechanical Behaviors of the Coronary Artery. J Biomech Eng 139:
Kim, Sungho; Giddens, Don P (2015) Mass transport of low density lipoprotein in reconstructed hemodynamic environments of human carotid arteries: the role of volume and solute flux through the endothelium. J Biomech Eng 137:041007
Tarbell, John M; Shi, Zhong-Dong; Dunn, Jessilyn et al. (2014) Fluid Mechanics, Arterial Disease, and Gene Expression. Annu Rev Fluid Mech 46:591-614
Wang, Ruoya; Gleason Jr, Rudolph L (2014) Residual shear deformations in the coronary artery. J Biomech Eng 136:061004
Campbell, Ian C; Suever, Jonathan D; Timmins, Lucas H et al. (2014) Biomechanics and inflammation in atherosclerotic plaque erosion and plaque rupture: implications for cardiovascular events in women. PLoS One 9:e111785
Nagaraja, Mamta Patel; Jo, Hanjoong (2014) The Role of Mechanical Stimulation in Recovery of Bone Loss-High versus Low Magnitude and Frequency of Force. Life (Basel) 4:117-30
Wang, Ruoya; Raykin, Julia; Li, Haiyan et al. (2014) Differential mechanical response and microstructural organization between non-human primate femoral and carotid arteries. Biomech Model Mechanobiol 13:1041-51
Son, Dong Ju; Kumar, Sandeep; Takabe, Wakako et al. (2013) The atypical mechanosensitive microRNA-712 derived from pre-ribosomal RNA induces endothelial inflammation and atherosclerosis. Nat Commun 4:3000
Zhang, Huanchun; Taylor, W Robert; Joseph, Giji et al. (2013) mRNA-binding protein ZFP36 is expressed in atherosclerotic lesions and reduces inflammation in aortic endothelial cells. Arterioscler Thromb Vasc Biol 33:1212-20
Wan, William; Gleason Jr, Rudolph L (2013) Dysfunction in elastic fiber formation in fibulin-5 null mice abrogates the evolution in mechanical response of carotid arteries during maturation. Am J Physiol Heart Circ Physiol 304:H674-86

Showing the most recent 10 out of 66 publications