Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL071589-02
Application #
6688339
Study Section
Lung Biology and Pathology Study Section (LBPA)
Program Officer
Berberich, Mary Anne
Project Start
2002-12-09
Project End
2007-11-30
Budget Start
2003-12-01
Budget End
2004-11-30
Support Year
2
Fiscal Year
2004
Total Cost
$356,625
Indirect Cost
Name
University of Pennsylvania
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104
Li, Shanru; Morley, Michael; Lu, MinMin et al. (2016) Foxp transcription factors suppress a non-pulmonary gene expression program to permit proper lung development. Dev Biol 416:338-46
Li, Shanru; Koziol-White, Cynthia; Jude, Joseph et al. (2016) Epithelium-generated neuropeptide Y induces smooth muscle contraction to promote airway hyperresponsiveness. J Clin Invest 126:1978-82
Spaeth, Jason M; Hunter, Chad S; Bonatakis, Lauren et al. (2015) The FOXP1, FOXP2 and FOXP4 transcription factors are required for islet alpha cell proliferation and function in mice. Diabetologia 58:1836-44
Snitow, Melinda E; Li, Shanru; Morley, Michael P et al. (2015) Ezh2 represses the basal cell lineage during lung endoderm development. Development 142:108-17
Herriges, Michael; Morrisey, Edward E (2014) Lung development: orchestrating the generation and regeneration of a complex organ. Development 141:502-13
Hogan, Brigid L M; Barkauskas, Christina E; Chapman, Harold A et al. (2014) Repair and regeneration of the respiratory system: complexity, plasticity, and mechanisms of lung stem cell function. Cell Stem Cell 15:123-38
Wang, Yi; Tian, Ying; Morley, Michael P et al. (2013) Development and regeneration of Sox2+ endoderm progenitors are regulated by a Hdac1/2-Bmp4/Rb1 regulatory pathway. Dev Cell 24:345-58
Li, Shanru; Wang, Yi; Zhang, Yuzhen et al. (2012) Foxp1/4 control epithelial cell fate during lung development and regeneration through regulation of anterior gradient 2. Development 139:2500-9
Wiehagen, Karla R; Corbo-Rodgers, Evann; Li, Shanru et al. (2012) Foxp4 is dispensable for T cell development, but required for robust recall responses. PLoS One 7:e42273
Rousso, David L; Pearson, Caroline Alayne; Gaber, Zachary B et al. (2012) Foxp-mediated suppression of N-cadherin regulates neuroepithelial character and progenitor maintenance in the CNS. Neuron 74:314-30

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