As for stroke, geographic and ethnic variations in CHD mortality are recognized but poorly understood. NIH (NINDS) supported the Reasons for Geographic And Racial Differences in Stroke (REGARDS) study to follow 30,000 individuals (age >44; 1/2 African American, 1/2 European American; 1/2 female; 1/2 from the stroke belt/ buckle areas) over 3.5 years for stroke incidence and mortality.
SPECIFIC AIMS. The overall goal of the REGARDS-MI Ancillary Study is to capitalize on a narrow window of opportunity to leverage REGARD'S infrastructure by quantifying geographic and ethnic variations in CHD mortality, attack rates (new and recurrent hospitalized acute CHD and pre-hospital CHD death in the population) and case fatality (among those with an acute CHD event, death within 28 days).
Our Specific Aims are to (1) estimate US geographic- and ethnic-specific rates of CHD mortality, attack rates, and case fatality; (2) study the relationship between US geographic- and ethnic-specific attack rates and variation in the prevalence of CHD risk factors; and (3) study the relationship between US geographic- and ethnic-specific CHD case fatality and socioeconomic factors, medical care and CHD risk factors. METHODS. We will retrieve medical records for all heart-related hospitalizations (about 6000) among REGARDS participants and collect data on all deaths (about 500). We will adjudicate hospitalizations and deaths for CHD, collect cardiac procedures and medications, and merge this with extensive data already being collected by REGARDS. Using multivariable multi-level analyses, we will test 10 specific hypotheses. IMPLICATIONS. This will be the first nationwide study to relate CHD attack rate and case fatality, including pre-hospital deaths, to geographic and ethnic variations in CHD mortality. REGARDS offers a unique opportunity to attain our specific aims without the massive participant recruitment and follow-up costs that otherwise would be necessary. There is no budgetary overlap between REGARDS and REGARDS-MI as REGARDS focuses only on potential strokes. Our results will contribute significantly to the knowledge base essential for attaining the Healthy People 2010 goal of reducing health disparities. ? ?

Agency
National Institute of Health (NIH)
Institute
National Heart, Lung, and Blood Institute (NHLBI)
Type
Research Project (R01)
Project #
5R01HL080477-02
Application #
7234357
Study Section
Special Emphasis Panel (ZRG1-HOP-G (90))
Program Officer
Aviles-Santa, Larissa
Project Start
2006-06-01
Project End
2011-04-30
Budget Start
2007-05-01
Budget End
2008-04-30
Support Year
2
Fiscal Year
2007
Total Cost
$705,017
Indirect Cost
Name
University of Alabama Birmingham
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
063690705
City
Birmingham
State
AL
Country
United States
Zip Code
35294
Colantonio, Lisandro D; Levitan, Emily B; Yun, Huifeng et al. (2018) Use of Medicare Claims Data for the Identification of Myocardial Infarction: The Reasons for Geographic And Racial Differences in Stroke Study. Med Care 56:1051-1059
Moise, Nathalie; Falzon, Louise; Obi, Megan et al. (2018) Interventions to Increase Depression Treatment Initiation in Primary Care Patients: a Systematic Review. J Gen Intern Med 33:1978-1989
Donnelly, John P; Lakkur, Sindhu; Judd, Suzanne E et al. (2018) Association of Neighborhood Socioeconomic Status With Risk of Infection and Sepsis. Clin Infect Dis 66:1940-1947
Mefford, Matthew T; Rosenson, Robert S; Cushman, Mary et al. (2018) PCSK9 Variants, Low-Density Lipoprotein Cholesterol, and Neurocognitive Impairment: Reasons for Geographic and Racial Differences in Stroke Study (REGARDS). Circulation 137:1260-1269
Myerson, Rebecca M; Colantonio, Lisandro D; Safford, Monika M et al. (2018) Does Identification of Previously Undiagnosed Conditions Change Care-Seeking Behavior? Health Serv Res 53:1517-1538
Colantonio, Lisandro D; Booth 3rd, John N; Bress, Adam P et al. (2018) 2017 ACC/AHA Blood Pressure Treatment Guideline Recommendations and Cardiovascular Risk. J Am Coll Cardiol 72:1187-1197
Inker, Lesley A; Grams, Morgan E; Levey, Andrew S et al. (2018) Relationship of Estimated GFR and Albuminuria to Concurrent Laboratory Abnormalities: An Individual Participant Data Meta-analysis in a Global Consortium. Am J Kidney Dis :
Akinyemiju, Tomi; Moore, Justin Xavier; Pisu, Maria et al. (2018) A Prospective Study of Obesity, Metabolic Health, and Cancer Mortality. Obesity (Silver Spring) 26:193-201
Blackburn, Justin; Albright, Karen C; Haley, William E et al. (2018) Men Lacking a Caregiver Have Greater Risk of Long-Term Nursing Home Placement After Stroke. J Am Geriatr Soc 66:133-139
Akinyemiju, Tomi; Moore, Justin Xavier; Judd, Suzanne E et al. (2018) Pre-diagnostic biomarkers of metabolic dysregulation and cancer mortality. Oncotarget 9:16099-16109

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