Sensory stimulation evokes in the central nervous system a complex series of neural events. With appropriate averaging techniques some of these events can be recorded from the human scalp and are called the averaged Evoked Potential (EP). The goal of this research is to develop EP analysis for the evaluation of disorders involving sensory dysfunction, and to further understand the neural basis of human sensory experience. Our strategy is to conduct, whenever possible, parallel studies in man and animals. Experiments are being conducted in five related areas: 1. Neural origins of EPs in man. The objective is to clarify the structures and pathways within the human brain which generate various EP components; such knowledge is fundamental both to basic and clinical studies. 2. Neural origins of EPs in non-human primates. In these studies we seek first to determine an optimal primate species for use as an animal model in human EP studies. In this species we will then carry out studies which cannot be performed on man with the object of further clarifying the neural origins and characteristics of EPs. 3. Clinical studies. We continue our investigation of EP correlates of epilepsy with the goal of determining EP alterations in different seizure types and assessing the effects of anticonvulsant medication. We are investigating the efficacy of SEP recording for assessment of cortical neurological status in Reye Syndrome. 4. Collection and quantification of normative data. Such data are necessary for proper interpretation of """"""""abnormal"""""""" responses from patients. 5. EP correlates of performance in cognitive tasks. By relating EPs to performance in well-defined reaction time paradigms, we may be able to separate those portions of EPs which are related to decision-making processes and to the subsequent motor act.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH005286-25
Application #
3374563
Study Section
Biopsychology Study Section (BPO)
Project Start
1977-12-01
Project End
1990-11-30
Budget Start
1986-12-01
Budget End
1987-11-30
Support Year
25
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Yale University
Department
Type
Schools of Medicine
DUNS #
082359691
City
New Haven
State
CT
Country
United States
Zip Code
06520
Lee, Su Mei; McCarthy, Gregory (2016) Functional Heterogeneity and Convergence in the Right Temporoparietal Junction. Cereb Cortex 26:1108-1116
Taylor, JohnMark; Shehzad, Zarrar; McCarthy, Gregory (2016) Electrophysiological correlates of face-evoked person knowledge. Biol Psychol 118:136-146
Kim, Na Yeon; McCarthy, Gregory (2016) Task influences pattern discriminability for faces and bodies in ventral occipitotemporal cortex. Soc Neurosci 11:627-36
Shultz, Sarah; van den Honert, Rebecca N; Engell, Andrew D et al. (2015) Stimulus-induced reversal of information flow through a cortical network for animacy perception. Soc Cogn Affect Neurosci 10:129-35
Lee, Su Mei; Gao, Tao; McCarthy, Gregory (2014) Attributing intentions to random motion engages the posterior superior temporal sulcus. Soc Cogn Affect Neurosci 9:81-7
Kim, Na Yeon; Lee, Su Mei; Erlendsdottir, Margret C et al. (2014) Discriminable spatial patterns of activation for faces and bodies in the fusiform gyrus. Front Hum Neurosci 8:632
Shultz, Sarah; McCarthy, Gregory (2014) Perceived animacy influences the processing of human-like surface features in the fusiform gyrus. Neuropsychologia 60:115-20
Engell, Andrew D; McCarthy, Gregory (2014) Face, eye, and body selective responses in fusiform gyrus and adjacent cortex: an intracranial EEG study. Front Hum Neurosci 8:642
Engell, Andrew D; McCarthy, Gregory (2014) Repetition suppression of face-selective evoked and induced EEG recorded from human cortex. Hum Brain Mapp 35:4155-62
Engell, Andrew D; McCarthy, Gregory (2013) Probabilistic atlases for face and biological motion perception: an analysis of their reliability and overlap. Neuroimage 74:140-51

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