In this competing renewal, we propose to continue two research themes concerned with the study of the visual processing of complex forms that were established during the current period of funding. The first concerns visual processing within the ventral occipitotemporal region of the human brain. We propose a series of experiments to investigate the degree to which processing in this region is category specific, and the degree to which processing is influenced by expertise. These studies will further attempt to determine whether processing within putative category specific regions are influenced by cognitive and attentional factors and, if so, when in time these factors influence processing. These latter studies will help determine the validity of our assertion that strong modularity may be temporally limited. The second line of inquiry concerns processing along the lateral temporal-parietal region - particularly within and near the superior temporal sulcus (STS). Our prior studies and those of other groups have indicated that this region is sensitive to the perception of biological motion such as shifts in eye gaze and mouth movements. We propose to systematically map this region to determine if indeed it is selectively influenced by biological as compared to complex non-biological motion and, if so, whether there is an organizational principle along the STS for the type of motion perceived, such as a somatotopic organization. Finally we will investigate whether activity in this region is sensitive to the social relevance of the perceived motion - whether the action is intentional, and whether the action is goal directed within the established context. As in our prior period of funding, we will conduct parallel studies using functional magnetic resonance imaging (functional MRI, or fMRI) and intracranial event-related potential (ERP) recording. This proposal will benefit from technological developments in high-field (4 Tesla or 4 T) neuroimaging that improve functional resolution, and from recent developments in pulse-sequence design that recover susceptibility-related signal loss in ventral temporal regions.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH005286-43
Application #
6827400
Study Section
Integrative, Functional and Cognitive Neuroscience 8 (IFCN)
Program Officer
Anderson, Kathleen C
Project Start
1977-12-01
Project End
2006-11-30
Budget Start
2004-12-01
Budget End
2005-11-30
Support Year
43
Fiscal Year
2005
Total Cost
$346,500
Indirect Cost
Name
Duke University
Department
Radiation-Diagnostic/Oncology
Type
Schools of Medicine
DUNS #
044387793
City
Durham
State
NC
Country
United States
Zip Code
27705
Lee, Su Mei; McCarthy, Gregory (2016) Functional Heterogeneity and Convergence in the Right Temporoparietal Junction. Cereb Cortex 26:1108-1116
Taylor, JohnMark; Shehzad, Zarrar; McCarthy, Gregory (2016) Electrophysiological correlates of face-evoked person knowledge. Biol Psychol 118:136-146
Kim, Na Yeon; McCarthy, Gregory (2016) Task influences pattern discriminability for faces and bodies in ventral occipitotemporal cortex. Soc Neurosci 11:627-36
Shultz, Sarah; van den Honert, Rebecca N; Engell, Andrew D et al. (2015) Stimulus-induced reversal of information flow through a cortical network for animacy perception. Soc Cogn Affect Neurosci 10:129-35
Lee, Su Mei; Gao, Tao; McCarthy, Gregory (2014) Attributing intentions to random motion engages the posterior superior temporal sulcus. Soc Cogn Affect Neurosci 9:81-7
Kim, Na Yeon; Lee, Su Mei; Erlendsdottir, Margret C et al. (2014) Discriminable spatial patterns of activation for faces and bodies in the fusiform gyrus. Front Hum Neurosci 8:632
Shultz, Sarah; McCarthy, Gregory (2014) Perceived animacy influences the processing of human-like surface features in the fusiform gyrus. Neuropsychologia 60:115-20
Engell, Andrew D; McCarthy, Gregory (2014) Face, eye, and body selective responses in fusiform gyrus and adjacent cortex: an intracranial EEG study. Front Hum Neurosci 8:642
Engell, Andrew D; McCarthy, Gregory (2014) Repetition suppression of face-selective evoked and induced EEG recorded from human cortex. Hum Brain Mapp 35:4155-62
Engell, Andrew D; McCarthy, Gregory (2013) Probabilistic atlases for face and biological motion perception: an analysis of their reliability and overlap. Neuroimage 74:140-51

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