This proposal is an extension of a prospective longitudinal study of 111 cross-situationally (pervasive) and 50 situationally hyperactive children who were evaluated at two time points: childhood (ages 5-12 years) and late adolescence (ages 16-24 years). The adult outcome (ages 25-28 years) of these subjects will be compared to 51 siblings of pervasive probands and 78 non-hyperactive controls who were evaluated in adolescence, and who will be assessed as part of the present proposal. Only one prospective study of the adult status of childhood hyperactivity has been reported. However, its sample of 21-33 year olds (mean-25 years) suffered from high attrition (40%). The proposed study will provide a wealth of information as well as a powerful means for furthering our understanding of this common childhood disorder. First, the pervasive, sibling, and control groups represent replication samples which will be compared to our ongoing prospective study of 115 pervasive probands, 100 normal controls, and 40 siblings of probands who are currently being evaluated as adults. Both pervasive proband groups were seen at the same childhood clinic (directed by the PI), systematically selected by the same criteria, and will be assessed by the same instruments at follow-up. Second, a low attrition is anticipated, judging from our high retrieval rate on a similar sample, and since our core staff has remained intact for hover 10 years. Third, this is the only study to prospectively follow situationally hyperactive children into adulthood. Fourth, the combined samples of 226 pervasive probands (evaluated at three time points) will allow us to study associations that no other investigator can, because of inadequate base rates of behaviors and syndromes. The following outcome variables are targeted for study: psychiatric status (assessed by trained clinicians and structured interviews); social adjustment (assessed by the Weissman Social Adjustment Scale); self-ratings of symptoms (SCL-90-R); intellectual functioning (WAIS-R, WRAT-R) academic skills (school records); criminal history (official arrest records); and stature (height measurements). This study will provide the opportunity to investigate how childhood and adolescent behavioral, cognitive, and neuropsychological characteristics contribute to adult status in the largest prospective sample of an entire cohort of hyperactive children objectively evaluated at three time points.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH018579-19
Application #
3374748
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1979-03-01
Project End
1993-04-30
Budget Start
1991-05-01
Budget End
1992-04-30
Support Year
19
Fiscal Year
1991
Total Cost
Indirect Cost
Name
Long Island Jewish Medical Center
Department
Type
DUNS #
City
New Hyde Park
State
NY
Country
United States
Zip Code
11040
Cortese, Samuele; Ramos Olazagasti, Maria A; Klein, Rachel G et al. (2013) Obesity in men with childhood ADHD: a 33-year controlled, prospective, follow-up study. Pediatrics 131:e1731-8
Cortese, Samuele; Imperati, Davide; Zhou, Juan et al. (2013) White matter alterations at 33-year follow-up in adults with childhood attention-deficit/hyperactivity disorder. Biol Psychiatry 74:591-8
Ramos Olazagasti, Maria A; Klein, Rachel G; Mannuzza, Salvatore et al. (2013) Does childhood attention-deficit/hyperactivity disorder predict risk-taking and medical illnesses in adulthood? J Am Acad Child Adolesc Psychiatry 52:153-162.e4
Mannuzza, Salvatore; Castellanos, Francisco X; Roizen, Erica R et al. (2011) Impact of the impairment criterion in the diagnosis of adult ADHD: 33-year follow-up study of boys with ADHD. J Atten Disord 15:122-9
Mannuzza, Salvatore; Klein, Rachel G; Moulton 3rd, John L (2008) Lifetime criminality among boys with attention deficit hyperactivity disorder: a prospective follow-up study into adulthood using official arrest records. Psychiatry Res 160:237-46
Mannuzza, Salvatore; Klein, Rachel G; Truong, Nhan L et al. (2008) Age of methylphenidate treatment initiation in children with ADHD and later substance abuse: prospective follow-up into adulthood. Am J Psychiatry 165:604-9
Mannuzza, S; Klein, R G; Bessler, A et al. (1993) Adult outcome of hyperactive boys. Educational achievement, occupational rank, and psychiatric status. Arch Gen Psychiatry 50:565-76
Klein, R G; Mannuzza, S (1991) Long-term outcome of hyperactive children: a review. J Am Acad Child Adolesc Psychiatry 30:383-7
Mannuzza, S; Klein, R G; Addalli, K A (1991) Young adult mental status of hyperactive boys and their brothers: a prospective follow-up study. J Am Acad Child Adolesc Psychiatry 30:743-51
Mannuzza, S; Klein, R G; Bonagura, N et al. (1991) Hyperactive boys almost grown up. V. Replication of psychiatric status. Arch Gen Psychiatry 48:77-83

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