This application requests support to continue the program of psychobiological research in the Department of Psychiatry, Emory University School of Medicine. The School of Medicine together with the Georgia Mental Health Institute wish to support a comprehensive research program that is basic to problems of brain function, behavior and mental health.
The aim i s to investigate the physiological and, in particular, the neuroendocrine basis of patterns of primate behavior. Emphasis is placed on patterns of instinctive and of emotional behavior, on the affectional and sexual responses, and also on the agonistic and aggressive responses. Central to this program is the accurate quantification of primate behavior using ethological techniques both in the dyadic situation and in the social group. We are concerned with understanding the physiological mechanisms that determine an animal's motivational state in terms of the underlying brain mechanisms involved. This necessitates utilization of brain implantation techniques with steroid hormones, operant conditioning techniques, and the radioimmunoassay of plasma steroids; emphasis is placed on a multidisciplinary approach. Detailed attention will be given to the mechanisms by which information concerning an animal's motivational state is communicated to conspecifics, and this necessitates an understanding of the informational content of behavioral displays, and also of the chemical communication signaling systems involved.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH019506-14S1
Application #
3374775
Study Section
(BPNB)
Project Start
1979-06-01
Project End
1987-11-30
Budget Start
1987-03-01
Budget End
1987-11-30
Support Year
14
Fiscal Year
1987
Total Cost
Indirect Cost
Name
Emory University
Department
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Clancy, A N; Michael, R P (1994) Effects of testosterone and aromatase inhibition on estrogen receptor-like immunoreactivity in male rat brain. Neuroendocrinology 59:552-60
Zumpe, D; Michael, R P (1994) Combined effects of Depo-Provera and Fadrozole on the sexual behavior of intact male cynomolgus monkeys (Macaca fascicularis). Physiol Behav 56:665-9
Clancy, A N; Whitman, C; Michael, R P et al. (1994) Distribution of androgen receptor-like immunoreactivity in the brains of intact and castrated male hamsters. Brain Res Bull 33:325-32
Michael, R P; Zumpe, D (1993) Medroxyprogesterone acetate decreases the sexual activity of male cynomolgus monkeys (Macaca fascicularis): an action on the brain? Physiol Behav 53:783-8
Zumpe, D; Bonsall, R W; Michael, R P (1993) Effects of the nonsteroidal aromatase inhibitor, fadrozole, on the sexual behavior of male cynomolgus monkeys (Macaca fascicularis). Horm Behav 27:200-15
Clancy, A N; Bonsall, R W; Michael, R P (1992) Immunohistochemical labeling of androgen receptors in the brain of rat and monkey. Life Sci 50:409-17
Bonsall, R W; Michael, R P (1992) Developmental changes in the uptake of testosterone by the primate brain. Neuroendocrinology 55:84-91
Bonsall, R W; Clancy, A N; Michael, R P (1992) Effects of the nonsteroidal aromatase inhibitor, Fadrozole, on sexual behavior in male rats. Horm Behav 26:240-54
Zumpe, D; Bonsall, R W; Kutner, M H et al. (1991) Medroxyprogesterone acetate, aggression, and sexual behavior in male cynomolgus monkeys (Macaca fascicularis). Horm Behav 25:394-409
Michael, R P; Bonsall, R W; Zumpe, D (1991) Medroxyprogesterone acetate and the nuclear uptake of testosterone and its metabolites by brain, pituitary gland and genital tract in male cynomolgus monkeys. J Steroid Biochem Mol Biol 38:49-57

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