Abstract

The overall objective of the proposed work is to understand the structure and organization of normal memory and its neurological foundations. We are studying the amnesic effects of electroconvulsive therapy (ECT), the noted patient N.A., and have recently established a population of Korsakoff patients. In addition we are studying memory as it is affected by normal aging, and by certain psychotropic drugs. A related goal of the research is to specify the risks of ECT to memory, and to define those current parameters associated with least memory loss.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH024600-13
Application #
3374894
Study Section
(PCBB)
Project Start
1979-01-01
Project End
1987-12-31
Budget Start
1986-01-01
Budget End
1986-12-31
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
University of California San Diego
Department
Type
Schools of Medicine
DUNS #
077758407
City
La Jolla
State
CA
Country
United States
Zip Code
92093

  Publications

Urgolites, Zhisen J; Hopkins, Ramona O; Squire, Larry R (2017) Medial temporal lobe and topographical memory. Proc Natl Acad Sci U S A 114:8626-8630
Squire, Larry R (2017) Memory for relations in the short term and the long term after medial temporal lobe damage. Hippocampus 27:608-612
Ocampo, Amber C; Squire, Larry R; Clark, Robert E (2017) Hippocampal area CA1 and remote memory in rats. Learn Mem 24:563-568
Smith, Christine N; Squire, Larry R (2017) When eye movements express memory for old and new scenes in the absence of awareness and independent of hippocampus. Learn Mem 24:95-103
Urgolites, Zhisen J; Kim, Soyun; Hopkins, Ramona O et al. (2016) Map reading, navigating from maps, and the medial temporal lobe. Proc Natl Acad Sci U S A 113:14289-14293
Sapiurka, Maya; Squire, Larry R; Clark, Robert E (2016) Distinct roles of hippocampus and medial prefrontal cortex in spatial and nonspatial memory. Hippocampus 26:1515-1524
Dede, Adam J O; Wixted, John T; Hopkins, Ramona O et al. (2016) Autobiographical memory, future imagining, and the medial temporal lobe. Proc Natl Acad Sci U S A 113:13474-13479
Dede, Adam J O; Frascino, Jennifer C; Wixted, John T et al. (2016) Learning and remembering real-world events after medial temporal lobe damage. Proc Natl Acad Sci U S A 113:13480-13485
Smith, Christine N; Jeneson, Annette; Frascino, Jennifer C et al. (2014) When recognition memory is independent of hippocampal function. Proc Natl Acad Sci U S A 111:9935-40
Smith, Christine N (2014) Retrograde memory for public events in mild cognitive impairment and its relationship to anterograde memory and neuroanatomy. Neuropsychology 28:959-72

Showing the most recent 10 out of 204 publications