Abstract

The program of research outlined in this proposal is designed to continue our attempts to develop a behavioral system in the marine mollusc Aplysia in which one can examine in appropriate cellular detail the mechanisms of a variety of short-term and long-term nonassociative and associative types of learning. Toward this end we plan in the proposed research to carry out three interrelated types of studies: 1) an analysis of the molecular mechanisms of two short-term nonassociative forms of behavioral modification habituation and sensitization, 2) an analysis of the relationships between a) short-term habituation and long-term habituation and b) between short-term sensitization and long-term sensitization, 3) an attempt to establish associative learning to analyze it on the cellular level.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH026212-13
Application #
3374948
Study Section
(BPNB)
Project Start
1977-09-01
Project End
1987-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
13
Fiscal Year
1986
Total Cost
Indirect Cost

  Institution

Name
Columbia University (N.Y.)
Department
Type
Schools of Medicine
DUNS #
064931884
City
New York
State
NY
Country
United States
Zip Code
10027

  Publications

Jin, Iksung; Udo, Hiroshi; Hawkins, Robert D (2011) Rapid increase in clusters of synaptophysin at onset of homosynaptic potentiation in Aplysia. Proc Natl Acad Sci U S A 108:11656-61
Jin, Iksung; Kandel, Eric R; Hawkins, Robert D (2011) Whereas short-term facilitation is presynaptic, intermediate-term facilitation involves both presynaptic and postsynaptic protein kinases and protein synthesis. Learn Mem 18:96-102
Antonov, Igor; Ha, Thomas; Antonova, Irina et al. (2007) Role of nitric oxide in classical conditioning of siphon withdrawal in Aplysia. J Neurosci 27:10993-1002
Hawkins, Robert D; Cohen, Tracey E; Kandel, Eric R (2006) Dishabituation in Aplysia can involve either reversal of habituation or superimposed sensitization. Learn Mem 13:397-403
Hawkins, Robert D; Clark, Gregory A; Kandel, Eric R (2006) Operant conditioning of gill withdrawal in Aplysia. J Neurosci 26:2443-8
Hawkins, Robert D; Kandel, Eric R; Bailey, Craig H (2006) Molecular mechanisms of memory storage in Aplysia. Biol Bull 210:174-91
Udo, Hiroshi; Jin, Iksung; Kim, Joung-Hun et al. (2005) Serotonin-induced regulation of the actin network for learning-related synaptic growth requires Cdc42, N-WASP, and PAK in Aplysia sensory neurons. Neuron 45:887-901
Jin, Iksung; Hawkins, Robert D (2003) Presynaptic and postsynaptic mechanisms of a novel form of homosynaptic potentiation at aplysia sensory-motor neuron synapses. J Neurosci 23:7288-97
Antonov, Igor; Antonova, Irina; Kandel, Eric R et al. (2003) Activity-dependent presynaptic facilitation and hebbian LTP are both required and interact during classical conditioning in Aplysia. Neuron 37:135-47
Antonova, I; Arancio, O; Trillat, A C et al. (2001) Rapid increase in clusters of presynaptic proteins at onset of long-lasting potentiation. Science 294:1547-50

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