Abstract

Two major sets of studies continue investigations into the pathology of the major functional psychoses. (a) Studies of smooth pursuit eye movement disorders have already been established as associated with psychosis (although it occurs in other conditions such as central nervous system and toxic disorders), and as having a genetic component. We now will try to clarify the central nervous system localization of pursuit disorders in psychosis and to explore the etiological significance of pursuit dysfunctions in studies of families with a high density for schizophrenia and in the Danish adoption sample. We will also develop and refine measures of saccadic reaction time. (b) We will continue studies of thought disorder using our Thought Disorder Index (TDI) for the purpose of discriminating types of thought disorder that are presumed to be associated with different functional psychoses and for detecting thought disorder in children with major psychopathology. We will also test the Danish adoption sample and high density families for the presence of thought disorder.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH031340-14
Application #
3375229
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1978-04-01
Project End
1992-03-31
Budget Start
1990-04-01
Budget End
1991-03-31
Support Year
14
Fiscal Year
1990
Total Cost
Indirect Cost

  Institution

Name
Harvard University
Department
Type
Schools of Arts and Sciences
DUNS #
071723621
City
Cambridge
State
MA
Country
United States
Zip Code
02138

  Publications

Morgan, Charity J; Coleman, Michael J; Ulgen, Ayse et al. (2017) Thought Disorder in Schizophrenia and Bipolar Disorder Probands, Their Relatives, and Nonpsychiatric Controls. Schizophr Bull 43:523-535
Deutsch, Curtis K; Levy, Deborah L; Price, Selya F R et al. (2015) Quantitative Measures of Craniofacial Dysmorphology in a Family Study of Schizophrenia and Bipolar Illness. Schizophr Bull 41:1309-16
Morgan, Charity J; Lenzenweger, Mark F; Rubin, Donald B et al. (2014) A hierarchical finite mixture model that accommodates zero-inflated counts, non-independence, and heterogeneity. Stat Med 33:2238-50
Coleman, Michael J; Titone, Debra; Krastoshevsky, Olga et al. (2010) Reinforcement ambiguity and novelty do not account for transitive inference deficits in schizophrenia. Schizophr Bull 36:1187-200
Krause, Verena; Krastoshevsky, Olga; Coleman, Michael J et al. (2010) Tailoring the definition of the clinical schizophrenia phenotype in linkage studies. Schizophr Res 116:133-42
Levy, Deborah L; Coleman, Michael J; Sung, Heejong et al. (2010) The Genetic Basis of Thought Disorder and Language and Communication Disturbances in Schizophrenia. J Neurolinguistics 23:176
Levy, Deborah L; Sereno, Anne B; Gooding, Diane C et al. (2010) Eye tracking dysfunction in schizophrenia: characterization and pathophysiology. Curr Top Behav Neurosci 4:311-47
Coleman, Michael J; Cestnick, Laurie; Krastoshevsky, Olga et al. (2009) Schizophrenia patients show deficits in shifts of attention to different levels of global-local stimuli: evidence for magnocellular dysfunction. Schizophr Bull 35:1108-16
McCarthy, Shane E; Makarov, Vladimir; Kirov, George et al. (2009) Microduplications of 16p11.2 are associated with schizophrenia. Nat Genet 41:1223-7
Sebat, Jonathan; Levy, Deborah L; McCarthy, Shane E (2009) Rare structural variants in schizophrenia: one disorder, multiple mutations; one mutation, multiple disorders. Trends Genet 25:528-35

Showing the most recent 10 out of 73 publications