Abstract

The long-term objective of this research is to examine diverse neural mechanisms of forms of behavioral choice, and the interactions of experience and of motivational state in choosing between behavioral alternatives. The research will use computational modelling techniques as well as intracellular microelectrode recording from individual neurons. Because of its experimental advantages, feeding behaviors executed by the buccal mass of the mollusc, Aplysia will be used as a model system for these studies. The research may provide clues to the principles by which higher nervous systems, including those of humans, generate behavioral decisions, and consequently the studies may aid in the eventual treatment of a large number of behavioral problems involving dysfunction of behavioral choice, such as schizophrenia, and compulsive disorders.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
7R01MH035564-30
Application #
6638960
Study Section
Special Emphasis Panel (ZRG1-IFCN-7 (01))
Project Start
1981-05-01
Project End
2004-04-30
Budget Start
2003-05-01
Budget End
2004-04-30
Support Year
30
Fiscal Year
2003
Total Cost
$338,263
Indirect Cost

  Institution

Name
Mount Sinai School of Medicine
Department
Physiology
Type
Schools of Medicine
DUNS #
078861598
City
New York
State
NY
Country
United States
Zip Code
10029

  Publications

Vilim, Ferdinand S; Sasaki, Kosei; Rybak, Jurgen et al. (2010) Distinct mechanisms produce functionally complementary actions of neuropeptides that are structurally related but derived from different precursors. J Neurosci 30:131-47
Friedman, Allyson K; Zhurov, Yuriy; Ludwar, Bjoern Ch et al. (2009) Motor outputs in a multitasking network: relative contributions of inputs and experience-dependent network states. J Neurophysiol 102:3711-27
Sasaki, Kosei; Brezina, Vladimir; Weiss, Klaudiusz R et al. (2009) Distinct inhibitory neurons exert temporally specific control over activity of a motoneuron receiving concurrent excitation and inhibition. J Neurosci 29:11732-44
Jing, Jian; Gillette, Rhanor; Weiss, Klaudiusz R (2009) Evolving concepts of arousal: insights from simple model systems. Rev Neurosci 20:405-27
Sasaki, Kosei; Jing, Jian; Due, Michael R et al. (2008) An input-representing interneuron regulates spike timing and thereby phase switching in a motor network. J Neurosci 28:1916-28
Sasaki, Kosei; Due, Michael R; Jing, Jian et al. (2007) Feeding CPG in Aplysia directly controls two distinct outputs of a compartmentalized interneuron that functions as a CPG element. J Neurophysiol 98:3796-801
Romanova, Elena V; McKay, Natasha; Weiss, Klaudiusz R et al. (2007) Autonomic control network active in Aplysia during locomotion includes neurons that express splice variants of R15-neuropeptides. J Neurophysiol 97:481-91
Jing, Jian; Vilim, Ferdinand S; Horn, Charles C et al. (2007) From hunger to satiety: reconfiguration of a feeding network by Aplysia neuropeptide Y. J Neurosci 27:3490-502
Hurwitz, Itay; Susswein, Abraham J; Weiss, Klaudiusz R (2005) Transforming tonic firing into a rhythmic output in the Aplysia feeding system: presynaptic inhibition of a command-like neuron by a CpG element. J Neurophysiol 93:829-42
Proekt, Alex; Vilim, Ferdinand S; Alexeeva, Vera et al. (2005) Identification of a new neuropeptide precursor reveals a novel source of extrinsic modulation in the feeding system of Aplysia. J Neurosci 25:9637-48

Showing the most recent 10 out of 60 publications