Publication of the revision of the DSM-III sets the occasion for a series of additional studies on the phenomenology, reliability, validity, and nature of anxiety disorder categories. Building on a series of studies on these topics conducted over the past several years we propose to examine a number of these issues. The Anxiety Disorders Interview Schedule, recently revised to be fully compatible with DSM-III-R will be utilized to determine the reliability of DSM-III-R categories using stringent test - retest methodology. Data will be collected from psychological test, physiological assessment, and periodic self-monitoring of relevant cognitive and behavioral events to ascertain similarities and differences among the DSM-III-R anxiety disorder categories as well as normals and two well-defined stress disorders, irritable bowel syndrome and hypertension. Response to CO2 challenges, and response and habituation to unexpected tones will comprise an important part of the physiological assessment. Patterns of co- morbidity will be determined for the anxiety disorder categories using hierarchy free methods and considering the functional relationships among disorders. In addition, key features of anxiety disorders based on a priori, clinical, or theoretical specification will be identified in terms of their presence or absence, as well as severity across the anxiety disorders. These key features will include panic, social anxiety, anxiety sensitivity, depression, worry, obsessions and compulsions and specific fears. All key features will be measured by questionnaire, interview, and possibly physiological responding. For example, responses to CO2 inhalations may be an index of anxiety sensitivity. Preliminary evidence from the first phase of this project indicates that many of these key features are present in other anxiety disorders (as well as the normal population) and that these features can be dimensionalized to provide profiles within each of the anxiety disorders with substantial implications for classification. Finally, patients in each of the reliably diagnosed DSM-III-R anxiety disorder categories will be followed for a period of two years to determine the course of these disorders and the stability of diagnostic categories and/or dimensional profiles.

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National Institute of Mental Health (NIMH)
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Treatment Development and Assessment Research Review Committee (TDA)
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State University of New York at Albany
Schools of Arts and Sciences
United States
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Conway, Christopher C; Brown, Timothy A (2018) Evaluating dimensional models of psychopathology in outpatients diagnosed with emotional disorders: A cautionary tale. Depress Anxiety 35:898-902
Rutter, Lauren A; Brown, Timothy A (2017) Psychometric Properties of the Generalized Anxiety Disorder Scale-7 (GAD-7) in Outpatients with Anxiety and Mood Disorders. J Psychopathol Behav Assess 39:140-146
Naragon-Gainey, Kristin; Prenoveau, Jason M; Brown, Timothy A et al. (2016) A comparison and integration of structural models of depression and anxiety in a clinical sample: Support for and validation of the tri-level model. J Abnorm Psychol 125:853-867
Conway, Christopher C; Rutter, Lauren A; Brown, Timothy A (2016) Chronic environmental stress and the temporal course of depression and panic disorder: A trait-state-occasion modeling approach. J Abnorm Psychol 125:53-63
Gallagher, Matthew W; Brown, Timothy A (2015) Bayesian Analysis of Current and Lifetime Comorbidity Rates of Mood and Anxiety Disorders In Individuals with Posttraumatic Stress Disorder. J Psychopathol Behav Assess 37:60-66
Rutter, Lauren A; Brown, Timothy A (2015) Reliability and validity of the dimensional features of generalized anxiety disorder. J Anxiety Disord 29:1-6
Bourgeois, Michelle L; Brown, Timothy A (2015) Perceived Emotion Control Moderates the Relationship between Neuroticism and Generalized Anxiety Disorder. Cognit Ther Res 39:531-541
Hettema, J M; Chen, X; Sun, C et al. (2015) Direct, indirect and pleiotropic effects of candidate genes on internalizing disorder psychopathology. Psychol Med 45:2227-36
Emmert-Aronson, Benjamin O; Brown, Timothy A (2015) An IRT Analysis of the Symptoms of Major Depressive Disorder. Assessment 22:332-40
Rosellini, Anthony J; Boettcher, Hannah; Brown, Timothy A et al. (2015) A Transdiagnostic Temperament-Phenotype Profile Approach to Emotional Disorder Classification: An Update. J Exp Psychopathol a2:110-128

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