The present study will compare the short-term and long-term effectiveness of self-control desensitization, self-control desensitization plus cognitive therapy, and cognitive therapy alone in the treatment of generalized anxiety disorder. Seventy-five clients will be diagnosed for primary generalized anxiety disorder by two independent psychiatric assessors using the Anxiety Disorders Interview Schedule, will complete a variety of pretherapy anxiety questionnaires and daily diaries, and will participate in a psychophysiological laboratory session which assesses peripheral and central physiological activity during several tasks of theoretical relevance to anxiety disorders. Subsequently, they will be provided 14 1.5-hour individual therapy sessions, after which posttherapy assessment will be repeated using the same psychiatric interview, questionnaires and diaries, and laboratory session. Two further therapy sessions will then be provided as fading sessions. Follow-up assessments will take place at 6 months, 12 months, and 24 months, and will include the psychiatric interview and questionnaires and diaries. The therapists will be two Ph.D. clinicians well-experienced in cognitive-behavioral treatment of anxiety disorders. A matched group of 75 nonanxious subjects will participate in the psychiatric interview and questionnaire sessions and will undergo the laboratory session, to provide normative information and as a contrast group for the physiological measures.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
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Treatment Development and Assessment Research Review Committee (TDA)
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Pennsylvania State University
Schools of Arts and Sciences
University Park
United States
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Newman, Michelle G; Lafreniere, Lucas S; Jacobson, Nicholas C (2018) Relaxation-induced anxiety: Effects of peak and trajectories of change on treatment outcome for generalized anxiety disorder. Psychother Res 28:616-629
Newman, Michelle G; Jacobson, Nicholas C; Erickson, Thane M et al. (2017) Interpersonal Problems Predict Differential Response to Cognitive Versus Behavioral Treatment in a Randomized Controlled Trial. Behav Ther 48:56-68
Newman, Michelle G; Shin, Ki Eun; Zuellig, Andrea R (2016) Developmental risk factors in generalized anxiety disorder and panic disorder. J Affect Disord 206:94-102
Fisher, Aaron J; Newman, Michelle G (2016) Reductions in the diurnal rigidity of anxiety predict treatment outcome in cognitive behavioral therapy for generalized anxiety disorder. Behav Res Ther 79:46-55
Newman, Michelle G; Castonguay, Louis G; Jacobson, Nicholas C et al. (2015) Adult attachment as a moderator of treatment outcome for generalized anxiety disorder: Comparison between cognitive-behavioral therapy (CBT) plus supportive listening and CBT plus interpersonal and emotional processing therapy. J Consult Clin Psychol 83:915-25
Newman, Michelle G; Przeworski, Amy; Consoli, Andrés J et al. (2014) A randomized controlled trial of ecological momentary intervention plus brief group therapy for generalized anxiety disorder. Psychotherapy (Chic) 51:198-206
Newman, Michelle G; Llera, Sandra J; Erickson, Thane M et al. (2013) Worry and generalized anxiety disorder: a review and theoretical synthesis of evidence on nature, etiology, mechanisms, and treatment. Annu Rev Clin Psychol 9:275-97
Newman, Michelle G; Fisher, Aaron J (2013) Mediated moderation in combined cognitive behavioral therapy versus component treatments for generalized anxiety disorder. J Consult Clin Psychol 81:405-14
Newman, Michelle G; Llera, Sandra J (2011) A novel theory of experiential avoidance in generalized anxiety disorder: a review and synthesis of research supporting a contrast avoidance model of worry. Clin Psychol Rev 31:371-82
Przeworski, Amy; Newman, Michelle G; Pincus, Aaron L et al. (2011) Interpersonal pathoplasticity in individuals with generalized anxiety disorder. J Abnorm Psychol 120:286-98

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