This application concerns the completion of analysis and reporting of a longitudinal investigation of psychiatric epidemiology, the Stirling County Study. Drawing on a combination of multiple cross-sectional surveys and several cohort follow-up investigations, the main objective is to contribute information about trends, incidence, and outcome regarding treated and untreated psychiatric disorders in a general population. The main bodies of data consist in: 1) self report of symptoms, impairment, and duration of depression and anxiety disorders through structured questionnaire interviews; and 2) reports by general physicians about the full range of psychiatric disorders. Such information was gathered between 1952 and 1970 about 2848 adult residents of a rapidly changing rural environment in eastern Canada. For the longitudinal study, computer programs were designed that substitute for earlier """"""""clinical evaluation"""""""" procedures. The first substantive results indicate that the prevalence of depression and anxiety disorders based on self report was 12.5% in a sample surveyed in 1952 and 12.7% in another sample surveyed in 1970. The stability of these prevalence rates is noteworthy.
The specific aims i nvolved in completing the study concern: 1) validity of the new computer methods based on using the results of five annual examinations carried out face-to-face by clinical psychiatrists for a subsample of 122 adults; 2) time trend estimates of prevalence based on general physician data; 3) incidence of different types of disorders based on cohort analysis; 4) psychiatric disorder outcomes such as recovery, relapses, chronicity, disability, and mortality; 5) relationships between treated and untreated disorders drawing not only on evidence of care provided by primary physicians but also by psychiatric specialty services as indicated in a case register of a local mental health center; 6) relationships among selected risk factors (organic medical disorders, economic position, social experiences, etc.) and the incidence, duration, and outcome of different types of psychiatric disorders; and 7) evaluation of an explorative trial in prevention.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH039576-03
Application #
3377435
Study Section
(EPSA)
Project Start
1984-09-30
Project End
1987-08-31
Budget Start
1986-09-01
Budget End
1987-08-31
Support Year
3
Fiscal Year
1986
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Colman, Ian; Kingsbury, Mila; Sucha, Ewa et al. (2018) Depressive and anxious symptoms and 20-year mortality: Evidence from the Stirling County study. Depress Anxiety 35:638-647
Gilman, Stephen E; Sucha, Ewa; Kingsbury, Mila et al. (2017) Depression and mortality in a longitudinal study: 1952-2011. CMAJ 189:E1304-E1310
Murphy, Jane M; Gilman, Stephen E; Lesage, Alain et al. (2010) Time trends in mortality associated with depression: findings from the Stirling County study. Can J Psychiatry 55:776-83
Murphy, J M; Leighton, A H (2009) Anxiety: its role in the history of psychiatric epidemiology. Psychol Med 39:1055-64
Murphy, J M; Horton, N J; Burke Jr, J D et al. (2009) Obesity and weight gain in relation to depression: findings from the Stirling County Study. Int J Obes (Lond) 33:335-41
Murphy, Jane M; Burke Jr, Jack D; Monson, Richard R et al. (2008) Mortality associated with depression: a forty-year perspective from the Stirling County Study. Soc Psychiatry Psychiatr Epidemiol 43:594-601
Litman, Heather J; Horton, Nicholas J; Murphy, Jane M et al. (2006) Marginal regression models with a time to event outcome and discrete multiple source predictors. Lifetime Data Anal 12:249-65
Murphy, J M; Horton, N J; Laird, N M et al. (2004) Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity. Acta Psychiatr Scand 109:355-75
Bassuk, Shari S; Murphy, Jane M (2003) Characteristics of the Modified Mini-Mental State Exam among elderly persons. J Clin Epidemiol 56:622-8
Murphy, Jane M; Horton, Nicholas J; Monson, Richard R et al. (2003) Cigarette smoking in relation to depression: historical trends from the Stirling County Study. Am J Psychiatry 160:1663-9

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