The purpose of this proposal is to build on information gathered recently as part of a longitudinal investigation of psychiatric epidemiology among adult samples of a general population. The overall objective is to provide a 40-year perspective on historical trends regarding psychiatric disorders. The site in Atlantic Canada has been given the pseudonym of """"""""Stirling County"""""""" for protection of identity.
The specific aims are to continue analysis of the accumulated body of data and to prepare a series of reports in which findings from the study will be described and, where appropriate, compared with those of recent studies. The study involves three repeated cross-sectional sample surveys (1952, 1970, and 1992) and two panel follow-up intervals (1952-1970- and 1970- 1992). Time trends will be reported regarding prevalence, incidence, clinical course, and mortality outcomes among approximately 4000 subjects. Two types of information have been gathered from the beginning of the investigation: 1.) structured interviews with subjects concerning depression, anxiety, and medical conditions.; and 2.) semi-structured interviews by psychiatrists with general physicians who have been named by subjects and asked about the medical and psychiatric histories of these subjects. The recent wave of data-gathering included administration of sections of the NIMH Diagnostic Interview Schedule and the Modified Mini-Mental Status Examination. Findings from these schedules will aid comparison to studies such as the NIMH Epidemiologic Catchment Area Program and the National Comorbidity Study, especially for common disorders such as those involving depression, anxiety, alcohol abuse, and cognitive dysfunction associated with aging. The risk factors and trends to be investigated include: birth cohort effects, aging, gender, changes in the role of women, socio-economic status, family history of psychiatric disorders, marriage and family patterns, religious/ethnic identity, and comorbidity between psychiatric and medical disorders and also within the psychiatric spectrum. The effects of health policy changes will be investigated since Canadian national health insurance was introduced into the area at the mid-point of the study interval. Analysis of data will make use of multivariate techniques such as loglinear analysis, survival regressions, and structural equation modelling. Reliability and validity of psychiatric diagnoses will be assessed.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH039576-14
Application #
2717293
Study Section
Epidemiology and Genetics Review Committee (EPI)
Program Officer
Bourdon, Karen H
Project Start
1984-09-30
Project End
2000-12-31
Budget Start
1998-01-01
Budget End
1998-12-31
Support Year
14
Fiscal Year
1998
Total Cost
Indirect Cost
Name
Massachusetts General Hospital
Department
Type
DUNS #
City
Boston
State
MA
Country
United States
Zip Code
02199
Colman, Ian; Kingsbury, Mila; Sucha, Ewa et al. (2018) Depressive and anxious symptoms and 20-year mortality: Evidence from the Stirling County study. Depress Anxiety 35:638-647
Gilman, Stephen E; Sucha, Ewa; Kingsbury, Mila et al. (2017) Depression and mortality in a longitudinal study: 1952-2011. CMAJ 189:E1304-E1310
Murphy, Jane M; Gilman, Stephen E; Lesage, Alain et al. (2010) Time trends in mortality associated with depression: findings from the Stirling County study. Can J Psychiatry 55:776-83
Murphy, J M; Leighton, A H (2009) Anxiety: its role in the history of psychiatric epidemiology. Psychol Med 39:1055-64
Murphy, J M; Horton, N J; Burke Jr, J D et al. (2009) Obesity and weight gain in relation to depression: findings from the Stirling County Study. Int J Obes (Lond) 33:335-41
Murphy, Jane M; Burke Jr, Jack D; Monson, Richard R et al. (2008) Mortality associated with depression: a forty-year perspective from the Stirling County Study. Soc Psychiatry Psychiatr Epidemiol 43:594-601
Litman, Heather J; Horton, Nicholas J; Murphy, Jane M et al. (2006) Marginal regression models with a time to event outcome and discrete multiple source predictors. Lifetime Data Anal 12:249-65
Murphy, J M; Horton, N J; Laird, N M et al. (2004) Anxiety and depression: a 40-year perspective on relationships regarding prevalence, distribution, and comorbidity. Acta Psychiatr Scand 109:355-75
Bassuk, Shari S; Murphy, Jane M (2003) Characteristics of the Modified Mini-Mental State Exam among elderly persons. J Clin Epidemiol 56:622-8
Murphy, Jane M; Horton, Nicholas J; Monson, Richard R et al. (2003) Cigarette smoking in relation to depression: historical trends from the Stirling County Study. Am J Psychiatry 160:1663-9

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