Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
3R01MH040537-10S1
Application #
2244994
Study Section
Neurosciences Research Review Committee (BPN)
Project Start
1985-04-01
Project End
1997-03-31
Budget Start
1994-04-01
Budget End
1995-03-31
Support Year
10
Fiscal Year
1995
Total Cost
Indirect Cost
Name
University of North Carolina Chapel Hill
Department
Internal Medicine/Medicine
Type
Schools of Medicine
DUNS #
078861598
City
Chapel Hill
State
NC
Country
United States
Zip Code
27599
Arnsten, Amy F T; Girgis, Ragy R; Gray, David L et al. (2017) Novel Dopamine Therapeutics for Cognitive Deficits in Schizophrenia. Biol Psychiatry 81:67-77
Lee, Sang-Min; Yang, Yang; Mailman, Richard B (2014) Dopamine D1 receptor signaling: does G?Q-phospholipase C actually play a role? J Pharmacol Exp Ther 351:9-17
Lee, Sang-Min; Kant, Andrew; Blake, Daniel et al. (2014) SKF-83959 is not a highly-biased functionally selective D1 dopamine receptor ligand with activity at phospholipase C. Neuropharmacology 86:145-54
Boyd, Kevin N; Mailman, Richard B (2012) Dopamine receptor signaling and current and future antipsychotic drugs. Handb Exp Pharmacol :53-86
Fowler, J Corey; Bhattacharya, Supriyo; Urban, Jonathan D et al. (2012) Receptor conformations involved in dopamine D(2L) receptor functional selectivity induced by selected transmembrane-5 serine mutations. Mol Pharmacol 81:820-31
Mailman, Richard B; Murthy, Vishakantha (2010) Ligand functional selectivity advances our understanding of drug mechanisms and drug discovery. Neuropsychopharmacology 35:345-6
Mailman, Richard B; Murthy, Vishakantha (2010) Third generation antipsychotic drugs: partial agonism or receptor functional selectivity? Curr Pharm Des 16:488-501
Brown, Justin T; Kant, Andrew; Mailman, Richard B (2009) Rapid, semi-automated, and inexpensive radioimmunoassay of cAMP: application in GPCR-mediated adenylate cyclase assays. J Neurosci Methods 177:261-6
Ryman-Rasmussen, Jessica P; Griffith, Adam; Oloff, Scott et al. (2007) Functional selectivity of dopamine D1 receptor agonists in regulating the fate of internalized receptors. Neuropharmacology 52:562-75
Urban, Jonathan D; Vargas, Gabriel A; von Zastrow, Mark et al. (2007) Aripiprazole has functionally selective actions at dopamine D2 receptor-mediated signaling pathways. Neuropsychopharmacology 32:67-77

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