The applicant proposes a seventh wave of data collection which will encompass a twenty year follow-up for a sample of 365 children identified at age five. The young adults will complete a structured interview which includes measures of DSM IV disorders, occupational and social functioning, interpersonal relationships, health, self esteem, self mastery, family milieu, social support, behavior problems, and use of mental health services. Parents (both mother and father) will be interviewed regarding history of psychiatric disorder in first degree relatives. Mothers will also provide information on aspects of age appropriate functioning.
The specific aims of the study are to: (1) examine prevalence, onset and extent of comorbidity of psychiatric disorders in young adults and their relationship to impairments in adult functioning; (2) assess the developmental course of disorders, suicidal and behavior problems in relation to past and current risk factors as well as the use of mental health services; (3) examine risk factors from all developmental periods predicting specific psychiatric disorders and the joint effect of early risks and current stressors on the onset of new disorders between ages 18-25; (4) study the role of family factors including family support, cohesion and history of disorders on the course of disorders and social and occupational adjustment in young adults; and (5) examine psychosocial factors from childhood to young adulthood fostering resistance to disorders (resilience) in those most at risk for disorder.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
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Child/Adolescent Risk and Prevention Review Committee (CAPR)
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Simmons College
Schools of Social Work
United States
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Paradis, Angela D; Giaconia, Rose M; Reinherz, Helen Z et al. (2011) Adolescent Family Factors Promoting Healthy Adult Functioning: A Longitudinal Community Study. Child Adolesc Ment Health 16:30-37
Tanner, Jennifer L; Reinherz, Helen Z; Beardslee, William R et al. (2007) Change in prevalence of psychiatric disorders from ages 21 to 30 in a community sample. J Nerv Ment Dis 195:298-306
Reinherz, Helen Z; Tanner, Jennifer L; Berger, Sasha R et al. (2006) Adolescent suicidal ideation as predictive of psychopathology, suicidal behavior, and compromised functioning at age 30. Am J Psychiatry 163:1226-32
Paradis, Angela D; Reinherz, Helen Z; Giaconia, Rose M et al. (2006) Major depression in the transition to adulthood: the impact of active and past depression on young adult functioning. J Nerv Ment Dis 194:318-23
Reinherz, Helen Z; Paradis, Angela D; Giaconia, Rose M et al. (2003) Childhood and adolescent predictors of major depression in the transition to adulthood. Am J Psychiatry 160:2141-7
Giaconia, R M; Reinherz, H Z; Paradis, A D et al. (2001) Major depression and drug disorders in adolescence: general and specific impairments in early adulthood. J Am Acad Child Adolesc Psychiatry 40:1426-33
Reinherz, H Z; Giaconia, R M; Hauf, A M et al. (2000) General and specific childhood risk factors for depression and drug disorders by early adulthood. J Am Acad Child Adolesc Psychiatry 39:223-31
Giaconia, R M; Reinherz, H Z; Hauf, A C et al. (2000) Comorbidity of substance use and post-traumatic stress disorders in a community sample of adolescents. Am J Orthopsychiatry 70:253-62
Frost, A K; Reinherz, H Z; Pakiz-Camras, B et al. (1999) Risk factors for depressive symptoms in late adolescence: a longitudinal community study. Am J Orthopsychiatry 69:370-81
Reinherz, H Z; Giaconia, R M; Hauf, A M et al. (1999) Major depression in the transition to adulthood: risks and impairments. J Abnorm Psychol 108:500-10

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