Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042088-10
Application #
2245341
Study Section
Clinical Neuroscience Review Committee (CNR)
Project Start
1991-09-01
Project End
1998-01-31
Budget Start
1996-02-01
Budget End
1997-01-31
Support Year
10
Fiscal Year
1996
Total Cost
Indirect Cost
Name
Emory University
Department
Psychiatry
Type
Schools of Medicine
DUNS #
042250712
City
Atlanta
State
GA
Country
United States
Zip Code
30322
Flandreau, Elizabeth I; Ressler, Kerry J; Owens, Michael J et al. (2012) Chronic overexpression of corticotropin-releasing factor from the central amygdala produces HPA axis hyperactivity and behavioral anxiety associated with gene-expression changes in the hippocampus and paraventricular nucleus of the hypothalamus. Psychoneuroendocrinology 37:27-38
Pariante, Carmine M; Nemeroff, Charles B (2012) Unipolar depression. Handb Clin Neurol 106:239-49
Hanson, Nicola D; Nemeroff, Charles B; Owens, Michael J (2011) Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. J Pharmacol Exp Ther 337:180-6
Hanson, Nicola D; Owens, Michael J; Boss-Williams, Katherine A et al. (2011) Several stressors fail to reduce adult hippocampal neurogenesis. Psychoneuroendocrinology 36:1520-9
Bonne, Omer; Gill, Jessica Mary; Luckenbaugh, David A et al. (2011) Corticotropin-releasing factor, interleukin-6, brain-derived neurotrophic factor, insulin-like growth factor-1, and substance P in the cerebrospinal fluid of civilians with posttraumatic stress disorder before and after treatment with paroxetine. J Clin Psychiatry 72:1124-8
Gutman, David A; Owens, Michael J; Thrivikraman, K V et al. (2011) Persistent anxiolytic affects after chronic administration of the CRFýýý receptor antagonist R121919 in rats. Neuropharmacology 60:1135-41
Coplan, Jeremy D; Abdallah, Chadi G; Kaufman, Joan et al. (2011) Early-life stress, corticotropin-releasing factor, and serotonin transporter gene: a pilot study. Psychoneuroendocrinology 36:289-93
Martin, Elizabeth I; Ressler, Kerry J; Binder, Elisabeth et al. (2010) The neurobiology of anxiety disorders: brain imaging, genetics, and psychoneuroendocrinology. Clin Lab Med 30:865-91
Binder, E B; Nemeroff, C B (2010) The CRF system, stress, depression and anxiety-insights from human genetic studies. Mol Psychiatry 15:574-88
Martin, Elizabeth I; Ressler, Kerry J; Jasnow, Aaron M et al. (2010) A novel transgenic mouse for gene-targeting within cells that express corticotropin-releasing factor. Biol Psychiatry 67:1212-6

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