Existing research on the adult outcome of children with Attention Deficit Hyperactivity Disorder (ADHD), or hyperactivity, indicates that they are at significant risk for academic failure, poor eventual educational attainment, antisocial behavior, poor social adjustment, and increased minor substance abuse (e.g., alcohol and cigarettes). Many will also experience poor occupational adjustment and increased risk of psychiatric disturbance. However, other areas of adult adjustment have not been explored or have received only cursory attention in past follow-up studies. The present proposal is for the continuation of a follow-up study of 158 hyperactive children and 81 matched normal control children first evaluated in 1979-80 and re-evaluated as adolescents 8 years later in 1987-88. This study would re-evaluate these subjects as young adults between 19 and 24 years of age over the 5 year period 1991-1996. The project would permit not only a detailed evaluation of these hyperactive and normal children as young adults, but would also permit their being tracked until they have children of their own. At that time, they would be solicited to participate in a second project, to be submitter later, on the parenting competence of these subjects and the psychiatric and social morbidity of their offspring. In the present project, efforts will be made to relocate as many prior subjects as possible to have them participate in two studies. Study #1 is a detailed, comprehensive assessment of the subjects as young adults with particular attention to evaluating their educational attainment, continuation of ADHD symptoms, psychiatric morbidity at adulthood, social and heterosocial adjustment, including sexual functioning, driving competence, antisocial behavior and substance abuse, and management of personal finances. An extensive battery of structured interviews, behavior rating scales completed by the subjects and their parents, laboratory tests of attention, impulse control, and activity level, direct behavioral observations, official registries of criminal acts and traffic violations/accidents, as well as direct assessment of intelligence, academic achievement, and response to mild punishment (response cost) contingencies will be used to evaluate all subjects. In Study #2, subjects in Study #1 will be solicited to participate in a direct assessment of driving competence using written tests, computer-simulated driving situations, and actual behind-the-wheel evaluations of driving abilities. Afterwards, all subjects will continue to be tracked as to their own marital and parental status for participation in our second project.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042181-09
Application #
2674882
Study Section
Clinical Psychopathology Review Committee (CPP)
Project Start
1987-04-01
Project End
2002-04-30
Budget Start
1998-05-01
Budget End
1999-04-30
Support Year
9
Fiscal Year
1998
Total Cost
Indirect Cost
Name
University of Massachusetts Medical School Worcester
Department
Psychiatry
Type
Schools of Medicine
DUNS #
660735098
City
Worcester
State
MA
Country
United States
Zip Code
01655
Barkley, Russell A; Fischer, Mariellen (2011) Predicting impairment in major life activities and occupational functioning in hyperactive children as adults: self-reported executive function (EF) deficits versus EF tests. Dev Neuropsychol 36:137-61
Barkley, Russell A; Fischer, Mariellen (2010) The unique contribution of emotional impulsiveness to impairment in major life activities in hyperactive children as adults. J Am Acad Child Adolesc Psychiatry 49:503-13
Fischer, Mariellen; Barkley, Russell A; Smallish, Lori et al. (2007) Hyperactive children as young adults: driving abilities, safe driving behavior, and adverse driving outcomes. Accid Anal Prev 39:94-105
Barkley, Russell A; Smith, Karen M; Fischer, Mariellen et al. (2006) An examination of the behavioral and neuropsychological correlates of three ADHD candidate gene polymorphisms (DRD4 7+, DBH TaqI A2, and DAT1 40 bp VNTR) in hyperactive and normal children followed to adulthood. Am J Med Genet B Neuropsychiatr Genet 141B:487-98
Barkley, Russell A; Fischer, Mariellen; Smallish, Lori et al. (2006) Young adult outcome of hyperactive children: adaptive functioning in major life activities. J Am Acad Child Adolesc Psychiatry 45:192-202
Smith, Karen Muller; Bauer, Lorri; Fischer, Mariellen et al. (2005) Identification and characterization of human NR4A2 polymorphisms in attention deficit hyperactivity disorder. Am J Med Genet B Neuropsychiatr Genet 133B:57-63
Fischer, Mariellen; Barkley, Russell A; Smallish, Lori et al. (2005) Executive functioning in hyperactive children as young adults: attention, inhibition, response perseveration, and the impact of comorbidity. Dev Neuropsychol 27:107-33
Barkley, Russell A; Fischer, Mariellen; Smallish, Lori et al. (2004) Young adult follow-up of hyperactive children: antisocial activities and drug use. J Child Psychol Psychiatry 45:195-211
Barkley, Russell A; Fischer, Mariellen; Smallish, Lori et al. (2003) Does the treatment of attention-deficit/hyperactivity disorder with stimulants contribute to drug use/abuse? A 13-year prospective study. Pediatrics 111:97-109
Smith, Karen Muller; Daly, Mark; Fischer, Mariellen et al. (2003) Association of the dopamine beta hydroxylase gene with attention deficit hyperactivity disorder: genetic analysis of the Milwaukee longitudinal study. Am J Med Genet B Neuropsychiatr Genet 119B:77-85

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