Abstract

The purpose of the research is to study the relationship between behavioral abnormalities in schizophrenia and abnormalities in brain anatomy and physiologic activity. The behavioral measures will be standardized clinical ratings and neuropsychological functioning. Anatomic assessment will include magnetic Resonance Imaging (MRI) volumetric measures. Physiologic parameters will be local cerebral glucose metabolism (1CMRg1), local cerebral blood flow (1CBF), local cerebral oxygen metabolism (1CMRO2) and Dopamine D-2 receptor density and affinity. Patients will be studied at the acute phase and following treatment. They will be followed up thereafter to assess the relation between the behavioral, anatomic and physiologic measures and clinical course.

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042191-03
Application #
3381292
Study Section
(SRCM)
Project Start
1987-01-01
Project End
1989-12-31
Budget Start
1989-01-01
Budget End
1989-12-31
Support Year
3
Fiscal Year
1989
Total Cost
Indirect Cost

  Institution

Name
University of Pennsylvania
Department
Type
Schools of Medicine
DUNS #
042250712
City
Philadelphia
State
PA
Country
United States
Zip Code
19104

  Publications

Kuo, Susan S; Almasy, Laura; Gur, Ruben C et al. (2018) Cognition and community functioning in schizophrenia: The nature of the relationship. J Abnorm Psychol 127:216-227
Dimitrion, Peter; Zhi, Yun; Clayton, Dennis et al. (2017) Low-Density Neuronal Cultures from Human Induced Pluripotent Stem Cells. Mol Neuropsychiatry 3:28-36
D'Aiuto, Leonardo; Williamson, Kelly; Dimitrion, Peter et al. (2017) Comparison of three cell-based drug screening platforms for HSV-1 infection. Antiviral Res 142:136-140
Kos, Mark Z; Carless, Melanie A; Peralta, Juan et al. (2017) Exome sequences of multiplex, multigenerational families reveal schizophrenia risk loci with potential implications for neurocognitive performance. Am J Med Genet B Neuropsychiatr Genet 174:817-827
Zhang, Xinjun; Li, Meng; Lin, Hai et al. (2017) regSNPs-splicing: a tool for prioritizing synonymous single-nucleotide substitution. Hum Genet 136:1279-1289
Bhatia, Triptish; Mazumdar, Sati; Wood, Joel et al. (2017) A randomised controlled trial of adjunctive yoga and adjunctive physical exercise training for cognitive dysfunction in schizophrenia. Acta Neuropsychiatr 29:102-114
Sekar, Aswin; Bialas, Allison R; de Rivera, Heather et al. (2016) Schizophrenia risk from complex variation of complement component 4. Nature 530:177-83
Ibrahim, Ibtihal; Salah, Hala; El Sayed, Hanan et al. (2016) Hepatitis C virus antibody titers associated with cognitive dysfunction in an asymptomatic community-based sample. J Clin Exp Neuropsychol 38:861-8
McNulty, James; D'Aiuto, Leonardo; Zhi, Yun et al. (2016) iPSC Neuronal Assay Identifies Amaryllidaceae Pharmacophore with Multiple Effects against Herpesvirus Infections. ACS Med Chem Lett 7:46-50
Kos, Mark Z; Carless, Melanie A; Peralta, Juan et al. (2016) Exome Sequence Data From Multigenerational Families Implicate AMPA Receptor Trafficking in Neurocognitive Impairment and Schizophrenia Risk. Schizophr Bull 42:288-300

Showing the most recent 10 out of 95 publications