Antisocial Personality Disorder is a virulent adult disorder that clearly has its origins in childhood conduct problems. There are critical gaps in our knowledge of the development of Antisocial Personality, however, that will be addressed by the proposed study. Although most previous studies suggest that all adults with Antisocial Personality met criteria for Conduct Disorder (CD) in childhood, some theorists posit that many adults with Antisocial Personality did not exhibit CD during childhood, but met criteria for Attention-Deficit Hyperactivity Disorder (ADHD) instead. We will address this important controversy by testing the hypothesis that CD always precedes Antisocial Personality developmentally. A corollary to our hypothesis is that boys with ADHD are, in fact, at increased risk for Antisocial Personality, but only if they exhibit comorbid oppositional defiant disorder (ODD) that leads to CD (usually prior to adolescence). The most important gap in current knowledge, however, stems from evidence suggesting that fewer than half of youths with CD eventually develop Antisocial Personality. There is a need to develop an adequate theory of the etiology of Antisocial Personality, so that we can distinguish between CD that is limited to childhood and adolescence and CD that is a stage in the development of Antisocial Personality. Once such knowledge is available, it will be possible to study Antisocial Personality at the time of its origination during childhood (and intervene at that time to prevent its development). For this purpose, we propose to continue a prospective study of clinic- referred boys begun eight years ago, and follow them into early adulthood to test our hypotheses about the development of Antisocial Personality. This prospective study will be the first to use data collected annually during childhood on CD and a wide range of relevant variables to determine the characteristics of youths with CD who go on to develop Antisocial Personality. In secondary analyses, we will also examine a broad range of developmental outcomes of children with disruptive behavior disorders who do not develop Antisocial Personality.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH042529-11
Application #
2445481
Study Section
Child Psychopathology and Treatment Review Committee (CPT)
Project Start
1987-04-01
Project End
2000-06-30
Budget Start
1997-07-01
Budget End
1998-06-30
Support Year
11
Fiscal Year
1997
Total Cost
Indirect Cost
Name
University of Pittsburgh
Department
Psychiatry
Type
Schools of Medicine
DUNS #
053785812
City
Pittsburgh
State
PA
Country
United States
Zip Code
15213
White, Helene R; Beardslee, Jordan; Pardini, Dustin (2017) Early predictors of maturing out of marijuana use among young men. Addict Behav 65:56-62
Bechtold, Jordan; Simpson, Theresa; White, Helene R et al. (2015) Chronic adolescent marijuana use as a risk factor for physical and mental health problems in young adult men. Psychol Addict Behav 29:552-63
Pardini, Dustin; Bechtold, Jordan; Loeber, Rolf et al. (2015) Developmental Trajectories of Marijuana Use among Men: Examining Linkages with Criminal Behavior and Psychopathic Features into the Mid-30s. J Res Crime Delinq 52:797-828
Pardini, Dustin; White, Helene R; Xiong, Shuangyan et al. (2015) Unfazed or Dazed and Confused: Does Early Adolescent Marijuana Use Cause Sustained Impairments in Attention and Academic Functioning? J Abnorm Child Psychol 43:1203-17
Burke, Jeffrey D; Rowe, Richard; Boylan, Khrista (2014) Functional outcomes of child and adolescent oppositional defiant disorder symptoms in young adult men. J Child Psychol Psychiatry 55:264-72
Kahn, Rachel E; Byrd, Amy L; Pardini, Dustin A (2013) Callous-unemotional traits robustly predict future criminal offending in young men. Law Hum Behav 37:87-97
Byrd, Amy L; Kahn, Rachel E; Pardini, Dustin A (2013) A Validation of the Inventory of Callous-Unemotional Traits in a Community Sample of Young Adult Males. J Psychopathol Behav Assess 35:
Burke, Jeffrey D (2012) An affective dimension within oppositional defiant disorder symptoms among boys: personality and psychopathology outcomes into early adulthood. J Child Psychol Psychiatry 53:1176-83
Keijsers, Loes; Loeber, Rolf; Branje, Susan et al. (2012) Parent-child relationships of boys in different offending trajectories: a developmental perspective. J Child Psychol Psychiatry 53:1222-32
Pardini, Dustin A; Loeber, Rolf; Farrington, David P et al. (2012) Identifying direct protective factors for nonviolence. Am J Prev Med 43:S28-40

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