The study addresses the distribution, validity and temporal stability of diagnosis in first-admission patients, patterns of illness course over a two-year period, and the prognostic utility and diagnostic specificity of a set of clinical and psychosocial indicators, in particular premorbid functioning, substance abuse, suicidal behavior, and treatment experiences. Under the current grant, we established cooperative agreements with 35 in- and outpatient facilities in Suffolk County, Long Island. In each facility, a liaison screens all admissions in order to refer first-admission psychotic patients to our project. The design entails a baseline, 6- and 24- month comprehensive diagnostic and psychosocial assessment, as well as continual contact with participants every 3 months. A consensus diagnosis is established by project psychiatrists at baseline, and a longitudinally-derived best-estimate diagnosis is determined after the 6- and 24-month assessments. The original funding was approved for 3 years to demonstrate the feasibility of establishing the network and to determine the actual numbers of eligible patients. We now anticipate that the intake phase to recruit a sample of 600 patients will be completed by 1994. During the first 16.5 months of field work, 182 patients were administered baseline interviews. Six-month best estimate diagnoses available for the first 56 patients indicate that the most common diagnosis is bipolar disorder (27%), followed by schizophrenia (21%), psychotic depression (13%), and schizoaffective disorder (13%). In addition, 46% of the 56 patients met criteria for a lifetime substance abuse or dependence. During the renewal period, we will complete the field and analytic phases of the study. We also plan to maintain contact with the sample beyond the 24 month interview to prepare for future research.

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH044801-06
Application #
2246224
Study Section
Epidemiologic and Services Research Review Committee (EPS)
Project Start
1989-05-01
Project End
1997-04-30
Budget Start
1994-05-01
Budget End
1995-04-30
Support Year
6
Fiscal Year
1994
Total Cost
Indirect Cost
Name
State University New York Stony Brook
Department
Psychiatry
Type
Schools of Medicine
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794
Strassnig, M; Kotov, R; Fochtmann, L et al. (2018) Associations of independent living and labor force participation with impairment indicators in schizophrenia and bipolar disorder at 20-year follow-up. Schizophr Res :
Strassnig, M; Cornacchio, D; Harvey, P D et al. (2017) Health status and mobility limitations are associated with residential and employment status in schizophrenia and bipolar disorder. J Psychiatr Res 94:180-185
Strassnig, Martin; Kotov, Roman; Cornaccio, Danielle et al. (2017) Twenty-year progression of body mass index in a county-wide cohort of people with schizophrenia and bipolar disorder identified at their first episode of psychosis. Bipolar Disord 19:336-343
Sabharwal, Amri; Kotov, Roman; Szekely, Akos et al. (2017) Neural markers of emotional face perception across psychotic disorders and general population. J Abnorm Psychol 126:663-678
Velthorst, Eva; Fett, Anne-Kathrin J; Reichenberg, Avraham et al. (2017) The 20-Year Longitudinal Trajectories of Social Functioning in Individuals With Psychotic Disorders. Am J Psychiatry 174:1075-1085
Kotov, Roman; Foti, Dan; Li, Kaiqiao et al. (2016) Validating dimensions of psychosis symptomatology: Neural correlates and 20-year outcomes. J Abnorm Psychol 125:1103-1119
Paksarian, Diana; Mojtabai, Ramin; Kotov, Roman et al. (2014) Perceived trauma during hospitalization and treatment participation among individuals with psychotic disorders. Psychiatr Serv 65:266-9
Jackson, Felicia; Foti, Dan; Kotov, Roman et al. (2014) An incongruent reality: the N400 in relation to psychosis and recovery. Schizophr Res 160:208-15
David Klonsky, E; Kotov, Roman; Bakst, Shelly et al. (2012) Hopelessness as a predictor of attempted suicide among first admission patients with psychosis: a 10-year cohort study. Suicide Life Threat Behav 42:1-10
Carlson, Gabrielle A; Kotov, Roman; Chang, Su-Wei et al. (2012) Early determinants of four-year clinical outcomes in bipolar disorder with psychosis. Bipolar Disord 14:19-30

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