Abstract

The relationship between characterological depression, or DSM-III-R primary early-onset dysthymia (PEOD), and the major affective and personality disorders has long been debated. The PI's preliminary work suggests that PEOD is a complex condition with links to both the major mood and personality disorders. The present proposal seeks to extend this work with a clinical and family study of PEOD. Subjects will include 100 outpatients with PEOD, 50 outpatients with episodic major depression (EMD), and 50 normal controls, and their first-degree relatives. Four major questions will be addressed: a. Is PEOD a more severe form of mood disorder than EMD from the standpoint of familial transmission? b. Which personality disorders are more common in PEOD than EMD? c. Other than mood disorders, are there other familial factors which distinguish PEOD from EMD? d. Which of five models of the relationships between PEOD and the major affective and Axis II disorders best explains the pattern of mood and personality disorders in relatives of PEOD, EMD, and normal probands?

  Funding Agency

Agency
National Institute of Health (NIH)
Institute
National Institute of Mental Health (NIMH)
Type
Research Project (R01)
Project #
5R01MH045757-02
Application #
3385605
Study Section
Psychopathology and Clinical Biology Research Review Committee (PCB)
Project Start
1991-04-01
Project End
1995-03-31
Budget Start
1992-04-01
Budget End
1993-03-31
Support Year
2
Fiscal Year
1992
Total Cost
Indirect Cost

  Institution

Name
State University New York Stony Brook
Department
Type
Schools of Arts and Sciences
DUNS #
804878247
City
Stony Brook
State
NY
Country
United States
Zip Code
11794

  Publications

Kopala-Sibley, Daniel C; Jelinek, Caitlin; Kessel, Ellen M et al. (2017) Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles. Dev Psychopathol 29:1469-1482
Kopala-Sibley, Daniel C; Klein, Daniel N; Perlman, Greg et al. (2017) Self-criticism and dependency in female adolescents: Prediction of first onsets and disentangling the relationships between personality, stressful life events, and internalizing psychopathology. J Abnorm Psychol 126:1029-1043
Qiu, Tianyou; Klonsky, E David; Klein, Daniel N (2017) Hopelessness Predicts Suicide Ideation But Not Attempts: A 10-Year Longitudinal Study. Suicide Life Threat Behav 47:718-722
Kopala-Sibley, Daniel C; Hayden, Elizabeth P; Singh, Shiva M et al. (2017) Gene-environment correlations in the cross-generational transmission of parenting: Grandparenting moderates the effect of child 5-HTTLPR genotype on mothers' parenting. Soc Dev 26:724-739
Kopala-Sibley, Daniel C; Klein, Daniel N (2017) Distinguishing types of social withdrawal in children: Internalizing and externalizing outcomes of conflicted shyness versus social disinterest across childhood. J Res Pers 67:27-35
Kopala-Sibley, Daniel C; Danzig, Allison P; Kotov, Roman et al. (2016) Negative emotionality and its facets moderate the effects of exposure to Hurricane Sandy on children's postdisaster depression and anxiety symptoms. J Abnorm Psychol 125:471-81
Klein, Daniel N; Kotov, Roman (2016) Course of depression in a 10-year prospective study: Evidence for qualitatively distinct subgroups. J Abnorm Psychol 125:337-48
Kopala-Sibley, D C; Kotov, R; Bromet, E J et al. (2016) Personality diatheses and Hurricane Sandy: effects on post-disaster depression. Psychol Med 46:865-75
Hershenberg, Rachel; Olino, Thomas M; Dyson, Margaret W et al. (2015) Are personality disorder dimensions related over time? An examination over the course of ten years using multivariate growth modeling. Compr Psychiatry 58:11-7
May, Alexis M; Klonsky, E David; Klein, Daniel N (2012) Predicting future suicide attempts among depressed suicide ideators: a 10-year longitudinal study. J Psychiatr Res 46:946-52

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