Dysthymia is a fairly prevalent condition with substantial social costs. As a nosological construct, it is defined and distinguished from major depression primarily on the basis of longitudinal course. Ironically, however, prospective data on the long-term course of dysthymia are extremely limited. The present proposal seeks funding to continue a ten- year naturalistic follow-up study of early-onset dysthymia, with four waves of assessments at 2 1 2-year intervals. Subjects will include 97 outpatients with DSM-III-R primary, early-onset dysthymia and a comparison group of 45 outpatients with non-chronic major depression. Assessments will include structured diagnostic interviews assessing Axis I and II disorders conducted blind to the baseline evaluation, a comprehensive battery of self-report questionnaires, interviews with knowledgeable informants, and review of medical records. The study will address six major issues: (1) the diagnostic stability of dysthymia; (2) the long-term naturalistic course of dysthymia; (3) clinical, psychosocial, and familial predictors of course and outcome; (4) the heterogeneity of early-onset dysthymia; (5) the stability of comorbid anxiety and personality disorders, and their relationship with dysthymia over time; and (6) the long-term course of social adjustment in dysthymia.

National Institute of Health (NIH)
National Institute of Mental Health (NIMH)
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Clinical Psychopathology Review Committee (CPP)
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State University New York Stony Brook
Schools of Arts and Sciences
Stony Brook
United States
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Kopala-Sibley, Daniel C; Jelinek, Caitlin; Kessel, Ellen M et al. (2017) Parental depressive history, parenting styles, and child psychopathology over 6 years: The contribution of each parent's depressive history to the other's parenting styles. Dev Psychopathol 29:1469-1482
Kopala-Sibley, Daniel C; Klein, Daniel N; Perlman, Greg et al. (2017) Self-criticism and dependency in female adolescents: Prediction of first onsets and disentangling the relationships between personality, stressful life events, and internalizing psychopathology. J Abnorm Psychol 126:1029-1043
Qiu, Tianyou; Klonsky, E David; Klein, Daniel N (2017) Hopelessness Predicts Suicide Ideation But Not Attempts: A 10-Year Longitudinal Study. Suicide Life Threat Behav 47:718-722
Kopala-Sibley, Daniel C; Hayden, Elizabeth P; Singh, Shiva M et al. (2017) Gene-environment correlations in the cross-generational transmission of parenting: Grandparenting moderates the effect of child 5-HTTLPR genotype on mothers' parenting. Soc Dev 26:724-739
Kopala-Sibley, Daniel C; Klein, Daniel N (2017) Distinguishing types of social withdrawal in children: Internalizing and externalizing outcomes of conflicted shyness versus social disinterest across childhood. J Res Pers 67:27-35
Kopala-Sibley, Daniel C; Danzig, Allison P; Kotov, Roman et al. (2016) Negative emotionality and its facets moderate the effects of exposure to Hurricane Sandy on children's postdisaster depression and anxiety symptoms. J Abnorm Psychol 125:471-81
Klein, Daniel N; Kotov, Roman (2016) Course of depression in a 10-year prospective study: Evidence for qualitatively distinct subgroups. J Abnorm Psychol 125:337-48
Kopala-Sibley, D C; Kotov, R; Bromet, E J et al. (2016) Personality diatheses and Hurricane Sandy: effects on post-disaster depression. Psychol Med 46:865-75
Hershenberg, Rachel; Olino, Thomas M; Dyson, Margaret W et al. (2015) Are personality disorder dimensions related over time? An examination over the course of ten years using multivariate growth modeling. Compr Psychiatry 58:11-7
May, Alexis M; Klonsky, E David; Klein, Daniel N (2012) Predicting future suicide attempts among depressed suicide ideators: a 10-year longitudinal study. J Psychiatr Res 46:946-52

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